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Pre-Sale Discount Ending June 30 June 29, 2015

Posted by Dreamhealer in Cancer, integrative cancer care, Naturopathic Medicine.
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Integrative Cancer Careintegrative cancer care vancouver

                                                                                                                                                 Just a reminder the presale discount for Dr. Adam McLeod’s new book, Integrative Cancer Care: The Power of Being Informed, ends tomorrow on Tuesday June 30, 2015! This book describes evidence based natural therapies that are available and how they can be used in an integrative cancer setting. Become an informed patient and get involved in your own healing.

Presale discount: $20 tax included

Regular price: $24.95 plus tax

Order your copy today through the online bookstore.

http://dreamhealer.3dcartstores.com/Integrative-Cancer-Care-The-Power-of-Being-Informed_p_20.html

Ketogenic Diet June 22, 2015

Posted by Dreamhealer in healthy fats, ketogenic diet, Naturopathic Medicine.
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Ketogenic Diet

By: Dr. Adam McLeod, ND, BSc (Hons)

The ketogenic diet is commonly used to treat epilepsy and it also appears to have applications in an integrative cancer setting as well. The concept behind the diet is that by changing the composition of the foods you eat it will fundamentally change the energy metabolism in your nervous system. The diet consists of consuming high amounts of fats while avoiding carbohydrates. This diet can be a challenge to maintain but in specific cases it is certainly worth the effort.

This high fat and low carbohydrate diet forces the body to burn fats for energy rather than sugars. Normally the brain uses glucose (sugar) as its primary source of energy but if there is a shortage of sugar the liver then converts fats into ketone bodies. These ketones pass into the brain and replace glucose as the primary source of energy. High levels of ketones in the blood are very strongly correlated with a decrease in the frequency of epileptic seizures.

Healthy cells within the nervous system are able to easily shift their metabolism to become dependent on ketone bodies. Cancerous cells within the nervous system have very high energetic requirements and they struggle to shift to this new energy source. As a result cancers that are of nervous tissue origin are vulnerable to the ketogenic diet. The ketogenic diet slows down the rate of growth of brain tumours because the cancerous cells do not have an abundant and useable energy source under these conditions2,3,4. In my experience the ketogenic diet works synergistically with DCA in patients with brain tumours. The evidence for the use of the ketogenic diet with brain cancers is overwhelming. There is also evidence to suggest that this diet can be helpful with other forms of cancer5. The results from the Ketogenic diet on brain tumours are far more dramatic than with other forms of cancer.

This diet is very difficult to maintain for long periods of time and it takes discipline to do it properly. I always recommend the ketogenic diet to patients with brain cancers, however, I do not regularly recommend it to patients with other forms of cancer. Although there is some evidence to suggest that it can still be helpful, it is often very stressful for patients to adhere to this strict diet plan. In advanced metastatic cases it can be helpful to begin the ketogenic diet because it slows down the rate of growth by changing the energy source for the cancer. In localized cancers that do not originate from the brain, the effect of the ketogenic diet is minimal. This diet is not a cure for cancer but it can certainly help to slow the growth and it can be used safely in conjunction with other medical treatments.

The reality is that in order for this diet to have the desired effect you need to strictly adhere to the diet plan. The goal is to starve the cancer cells of their primary energy source, every time you consume sugar they immediately use this to produce energy. There are a number of good online resources that can help you transition to an effective ketogenic diet. One good website is:

http://www.ketogenic-diet-resource.com

Often when making such a dramatic dietary change the key to success is slowly transitioning to the new diet. In this circumstance it is best to make the transition as rapidly as possible and resources like the above website can help with that transition. It is very important to consult a Naturopathic doctor to determine if this is the right diet for you. This diet is not for everyone and it takes clinical judgement to determine if this is best option.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author.
He currently practices at his clinic, Yaletown Naturopathic Clinic, in Vancouver, BC where he focuses on integrative oncology.

References:
1) Freeman JM, Kossoff EH, Hartman AL. The ketogenic diet: one decade later. Pediatrics. 2007 Mar;119(3):535–43.

2) Zhou, Weihua, et al. “The calorically restricted ketogenic diet, an effective alternative therapy for malignant brain cancer.” Nutr Metab (Lond) 4.5 (2007): 5.

3) Nebeling, Linda C., et al. “Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports.” Journal of the American College of Nutrition 14.2 (1995): 202-208.

4) Seyfried, Thomas N., and Purna Mukherjee. “Targeting energy metabolism in brain cancer: review and hypothesis.” Nutrition & metabolism 2.1 (2005): 30.

5) Schmidt, Melanie, et al. “Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial.” Nutr Metab (Lond) 8.1 (2011): 54.

The Dangers of DHEA June 15, 2015

Posted by Dreamhealer in Alternative medicine, Breast Cancer, Cancer, Cancer Treatment.
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DHEA Cancer

Written by: Dr. Adam McLeod, ND, BSc (Hons)

DHEA (Dehydroepiandrosterone) is often described as a wonder drug that is used by patients interested in its anti-aging effects. As we age the levels of DHEA in the blood start to decrease so the logic was that if patients were given this hormone then they would be able to partially reverse the aging process. There is evidence to suggest that indeed it improves many of the characteristics that we associate with aging.

Supplementation with DHEA is not safe for everyone as it is strongly associated with an increased risk of developing breast cancer1,2. In response to this risk, supplement companies began to produce a molecule called 7-keto DHEA, which is a metabolite of DHEA. This was considered a safer alternative to DHEA because it does not break down into estrogen or testosterone4. It is true that when patients take 7-keto DHEA there is no statistically significant increase in hormone levels but this does not make it safe to use with breast cancer.

I have personally seen several patients with active estrogen positive breast cancer who were prescribed 7-keto DHEA by a medical doctor. This is a dangerous combination and it is reckless to prescribe this medication in this clinical situation. 7-keto DHEA is not safe for any patient with estrogen positive breast cancer. There are a number of obvious biochemical reasons for this contraindication. First of all there are absolutely no studies which indicate that this is safe with estrogen positive breast cancer. Secondly, just because the estrogen levels are not elevated does not mean that the estrogen receptor is not being stimulated.

Normally the receptors on the surface of a cell are only stimulated by a few specific molecules. The estrogen receptors are notoriously promiscuous. What this means is that they are stimulated by many different molecules as well as estrogen. One of those molecules is 7-keto DHEA. In other words, even though patients do not have elevations in estrogen levels the estrogen receptors are being directly stimulated by the 7-keto DHEA3. As far as the cancer cells are concerned, they will act as if they are being stimulated by estrogen even though the actual levels of estrogen remain unchanged.

In one study it was conclusively shown that 7-keto DHEA (aka 7-oxo DHEA) is a low affinity ligand activator of estrogen receptors. The estrogen activity in these cancer cell lines were significantly elevated compared to the controls. In this same study, the cancer cells (MCF-7 breast cancer cells) that were treated with 7-keto DHEA grew much faster than the controls. This simple study certainly raises concern about the use of this supplement in cancer patients. It is clearly misleading to state that 7-keto DHEA has all the positive effects of DHEA without any of the negative effects. This is simply not how our cells operate on the biochemical level.

Another obvious concern is that 7-keto DHEA is essentially structurally identical to DHEA. This means that its overall shape is so similar that it will stimulate estrogen receptors the same as if it was DHEA. The estrogen receptors on cancer cells cannot tell the difference between 7-keto DHEA and DHEA. As far as the cancer is concerned it is the same thing. Of course the DHEA will not stimulate these receptors as strongly as estrogen but they still increase the activity which is the complete opposite of what you want to do with estrogen positive breast cancer. Conventional cancer therapies work very hard to reduce estrogen activity as much as possible because this activity acts as a signal for these cancer cells to grow5.

It is important that more patients become aware of this serious concern because it is difficult to sift through the mountains of information on the web. Unfortunately, there are still doctors that are prescribing this medication to estrogen positive breast cancer patients. The simple explanation that estrogen levels are unaffected does not mean that it is safe. Biology is much more complex than simply monitoring the level of a few arbitrary hormones in the blood. There is significant cross talk between these different pathways in cells and this well understood biological concept also applies to the clinical setting.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author.
He currently practices at his clinic, Yaletown Naturopathic Clinic, in Vancouver, BC where he focuses on integrative oncology.

References:
1) Tworoger, S. S.; Missmer, S. A.; Eliassen, A. H. et al. (2006). “The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women”. Cancer Epidemiol. Biomarkers Prev. 15 (5): 967–71.

2) Key, T.; Appleby, P.; Barnes, I.; Reeves, G. (2002). “Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies”. J. Natl. Cancer Inst. 94 (8): 606–16.

3) Michael Miller, Kristy K., et al. “DHEA metabolites activate estrogen receptors alpha and beta.” Steroids 78.1 (2013): 15-25.

4) Lardy, H; Kneer N, Wei Y, Partridge B, Marwah P (1998). “Ergosteroids II: Biologically Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone”. Steroids 63 (3): 158–165.

5) Janni W, Hepp P. Adjuvant aromatase inhibitor therapy: Outcomes and safety. Cancer Treat Rev. 2010; 36:249–261.

Iron and Anemia in Cancer Patients June 9, 2015

Posted by Dreamhealer in Alternative medicine, Anemia, Cancer, iron deficiency.
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iron anemia cancer
Written by: Dr. Adam McLeod, ND, BSc (Hons)

Everyone has seen someone with cancer who looks pale and depleted with energy. This is often due to anemia which means that there are less red blood cells to transport oxygen to tissues in the body. There are a number of different potential causes for this and one of the most common causes is low iron. When a doctor looks at blood work that clearly says “low iron” there is often an immediate response to supplement the patient with iron. However, we should not be so quick to prescribe iron to every cancer patient that is showing signs of anemia.

The interactions between iron and cancer are very complex and altered iron metabolism is considered a key metabolic “hallmark of cancer”1. It is clear that iron has roles in all aspects of cancer development, including the tumour microenvironment and metastasis. As evidenced by the expression pattern of ‘iron genes’ in malignant tumours, it is not simply associated with cancer, but also is indicative of a patient’s chances of survival2.

Our bodies have evolved to tightly partition and limit the amount of available iron. The iron deficiency anemia that is observed in cancer patients may actually be the bodies response to the presence of cancer. By limiting the availability of iron in circulation, there is less available for the cancer to utilize. If the patient is given iron then you are essentially fighting against the bodies effort to lower the iron levels.

There are a number of different studies that clearly show a strong connection between low iron levels and decreased cancer risk. It is well documented that people who regularly donate blood have lower rates of developing cancer3. This is likely connected to decreased iron levels following donation of blood. A popular natural cancer therapy called curcumin, acts as a potent natural chelator of iron5. It is thought that some of the observed anti-cancer properties might be due to the fact that it powerfully sequesters iron away from cancer cells6.

Recent research indicates that tumours create their own iron-rich micro-environment to evade constraints that are imposed by limited systemic iron availability. Cancer cells will sequester iron and it is possible that this allows the cancer cells to mutate more quickly. Iron reacts with oxygen to produce free radicals that damage DNA. Normally this is not desirable, however, this allows cancer cells to adapt more quickly to different conditions when the DNA is being constantly damaged on a low level. This consistent damage from excess iron is thought to increase the mutation rate of the DNA within the cancer cells. This recent evidence for regulation of iron in the tumour micro-environment represents a new paradigm in iron biology4.

Of course there are some situations where iron must be prescribed but it should not be done unnecessarily. Many effective cancer therapies work by actually decreasing the level of iron in the blood. If the red blood cells are reduced in number and smaller than normal (low MCV) then you very likely have iron deficiency anemia. It is very important to also check the level of ferritin to check on your bodies ability to transport iron.

A Naturopathic doctor that works with oncology will take the time to look at your case and will write you a prescription for iron if it is truly indicated. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author.
He currently practices at his clinic, Yaletown Naturopathic Clinic, in Vancouver, BC where he focuses on integrative oncology.

References:
1) Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. 2011;144:646–674. [PubMed]

2) Miller LD, et al. An iron regulatory gene signature predicts outcome in breast cancer. Cancer Res. 2011;71:6728–6737. [PMC free article]

3) Edgren G, et al. Donation frequency, iron loss, and risk of cancer among blood donors. J. Natl Cancer Inst. 2008;100:572–579. [PubMed]

4) Torti, Suzy V., and Frank M. Torti. “Iron and cancer: more ore to be mined.” Nature Reviews Cancer 13.5 (2013): 342-355.

5) Jiao Y, et al. Iron chelation in the biological activity of curcumin. Free Radic. Biol. Med. 2006;40:1152–1160. [PubMed]

6) Jiao Y, et al. Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator. Blood. 2009;113:462–469. [PMC free article]

What Every Patient Should Know Before Surgery May 27, 2015

Posted by Dreamhealer in Healing, Surgery, Vitamin C.
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surgery vancouver naturopath
By: Dr. Adam McLeod, ND, BSc (Hons)

Surgery is sometimes necessary and depending on the procedure it can take quite some time for patients to heal. It is important for every patient to know that there are therapies available that help to promote wound healing post surgery. Every surgical procedure is stressful on the body and this stress changes the metabolic requirements in your cells. As the body puts energy into wound healing several nutrients suddenly become in high demand. For optimal wound healing it is essential that these nutrients are supplied.

Collagen is a key component of the wound healing process. Vitamin C is essential post surgery as it is required for proper collagen formation1,2. The enzymes that produce and stabilize collagen require significant amounts of Vitamin C. It is well established that patients who smoke are very slow to heal from surgery. This is because cigarette smoke is very oxidative which results in a rapid depletion of Vitamin C in the tissues3. With inadequate supplies of this essential nutrient the collagen is slow to form and the collagen that does form tends to be weak. As a consequence wounds are more likely to break open after the surgery due to their inability to heal. It has been known for decades that when patients are supplemented with Vitamin C they heal faster after surgery4.

Another nutrient that is very important with regards to wound healing in zinc. Many of the enzymes that are directly required for wound healing are dependent on a sufficient supply of zinc. Patients with a genetic predisposition to zinc deficiency have significantly impaired wound healing capabilities5. After a traumatic event such as a surgery the requirements for zinc in the body are significantly higher. When patients are supplemented with zinc they heal faster as they are able to meet this obvious metabolic requirement5.

Vitamin A is another nutrient that must be supplied in adequate amounts for proper wound healing to occur. Patients with a deficiency in Vitamin A are very poor at healing wounds6. The role of Vitamin A in wound healing is different than that of zinc and Vitamin C. It is likely that the wound healing properties of Vitamin A are due to its ability to regulate the immune system locally in a way that is conducive to tissue repair.

Not only should patients be supplemented with these basic nutrients, their diet should be altered to help promote tissue healing as well. The patient must significantly increase their protein intake while avoiding inflammatory foods. All of these simple changes make a profound difference in the healing process. These natural approaches are well supported by scientific evidence but they are not commonly encouraged by surgeons. This is very often due to their lack of training in nutrition.

If you have an upcoming surgery make sure that you contact a Naturopathic doctor to help you develop a plan that will accelerate the healing after the surgery is complete. It is very important to have professional guidance from a Naturopathic physician when you are preparing for a surgery. The dose and the quality of the supplements makes a huge difference. Some of the recommended approaches are contraindicated in certain conditions and it takes an expert to develop a plan that is both safe and effective. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References:

1) MacKay, Douglas, and Alan L. Miller. “Nutritional support for wound healing.” Alternative medicine review: a journal of clinical therapeutic 8.4 (2003): 359-377.

2) Boyera, N., I. Galey, and B. A. Bernard. “Effect of vitamin C and its derivatives on collagen synthesis and cross‐linking by normal human fibroblasts.” International Journal of Cosmetic Science 20.3 (1998): 151-158.

3) Schectman, Gordon, James C. Byrd, and Harvey W. Gruchow. “The influence of smoking on vitamin C status in adults.”American Journal of Public Health 79.2 (1989): 158-162.

4) Bartlett, Marshall K., Chester M. Jones, and Anna E. Ryan. “Vitamin C and wound healing: II. Ascorbic acid content and tensile strength of healing wounds in human beings.” New England Journal of Medicine 226.12 (1942): 474-481.

5) Lansdown, Alan BG, et al. “Zinc in wound healing: theoretical, experimental, and clinical aspects.” Wound Repair and Regeneration 15.1 (2007): 2-16.

6) Hunt, Thomas K. “Vitamin A and wound healing.” Journal of the American Academy of Dermatology 15.4 (1986): 817-821.

Heartburn Medications and Cancer May 12, 2015

Posted by Dreamhealer in Healing.
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heartburn acid reflux

Written by: Dr. Adam McLeod, ND, BSc(Hons)

Many cancer patients undergoing chemotherapy have constant disturbances in their gastrointestinal tract. Heartburn is very common in these patients and it is frequently treated with a class of drugs called proton pump inhibitors (PPI’s). Some common PPI’s are Pariet, Losec, Nexium and Tecta. There is no question that these drugs are effective at controlling heart burn symptoms. These drugs dramatically suppress the stomach’s ability to produce acid. When patients are on these drugs long term it can be difficult to discontinue them because heart burn symptoms reappear whenever they miss a dose. In the context of cancer there are other options that can be considered before using PPI’s.

There is a class of drugs called H2-receptor antagonists and these drugs are also very effective at reducing stomach acid production. The reduction in stomach acid tends to be short term and patients do not become as dependent on these medications compared to PPI’s. The most researched drug of this class in the context of cancer is Cimetidine, also known as Tagamet. There is a substantial body of evidence which indicates that Tagamet is also an effective adjunctive cancer therapy1,2,3,4. The conclusion from one major study was, “These results clearly indicate that Cimetidine treatment dramatically improved survival in colorectal cancer patients with tumour cells expressing high levels of sLx and sLa.”1

An interesting double blind study was completed in 1988 which showed that survival was significantly enhanced in patients who took cimetidine 400mg two times per day for 2 years after gastric cancer surgery6. Many of these gastrointestinal cancers are stimulated by histamine and cimetidine blocks this effect7. The use of cimetidine as an adjunctive cancer therapy tends to be very indicated for gastric and colon cancers.

The exact mechanism of this anti-cancer effect is still not fully understood. Cimetidine is thought to target a class of molecules known as cadherins and by doing so it reduces the risk of metastasis. In Asia it is commonly used in conjunction with the chemotherapy 5-FU to treat colorectal cancers and this has resulted in significant increases in patient survival1. It appears that there are other pathways involved with this anti-cancer effect. Regardless of the mechanism it is clear that this medication has potential as an adjunctive cancer therapy in patients with colorectal cancer.

It is important to point out that this drug is not appropriate for everyone as there are a number of potential interactions. It is metabolized through the P450 pathway5 and this is the same pathway that many other drugs are metabolized through. This is not an absolute contraindication but you have to be careful about the dosing and often it is best to slowly introduce the Cimetidine. It is essential that you have a Naturopathic oncologist who is familiar with the use of Cimetidine look through all of your medications to determine if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. Vist Yaletown Naturopathic Clinic for more information.

References:

1) Matsumoto, S., et al. “Cimetidine increases survival of colorectal cancer patients with high levels of sialyl Lewis-X and sialyl Lewis-A epitope expression on tumour cells.” British journal of cancer 86.2 (2002): 161-167.

2) Kobayashi, Ken-ichi, et al. “Cimetidine inhibits cancer cell adhesion to endothelial cells and prevents metastasis by blocking E-selectin expression.” Cancer research 60.14 (2000): 3978-3984.

3) Kubecova, Martina, et al. “Cimetidine: An anticancer drug?.” European Journal of Pharmaceutical Sciences 42.5 (2011): 439-444.

4) Bolton, Elaine, Julie King, and David L. Morris. “H2-antagonists in the treatment of colon and breast cancer.” Seminars in cancer biology. Vol. 10. No. 1. Academic Press, 2000.

5) Levine M, Law EY, Bandiera SM, Chang TK, Bellward GD (February 1998). “In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats”. The Journal of Pharmacology and Experimental Therapeutics 284 (2): 493–9.

6) Burtin, Claude, et al. “Clinical improvement in advanced cancer disease after treatment combining histamine and H2-antihistaminics (ranitidine or cimetidine).” European Journal of Cancer and Clinical Oncology 24.2 (1988): 161-167.

7) Adams, W. J., J. A. Lawson, and D. L. Morris. “Cimetidine inhibits in vivo growth of human colon cancer and reverses histamine stimulated in vitro and in vivo growth.” Gut 35.11 (1994): 1632-1636.

“My Doctor told me to avoid Blueberries? But Chocolate is ok!” April 28, 2015

Posted by Dreamhealer in Alternative medicine, Cancer, Integrative Medicine.
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blueberries_and_cancer-diet

Written by: Dr. Adam McLeod, ND, BSc(Hons)

I frequently hear from patients that their Medical Doctor bluntly told them to forget changing their diet because it does not make a difference, even though this is not accurate based on a large body of scientific evidence. I was very surprised to hear a patient tell me that their doctor told them to specifically avoid blueberries. This was the only dietary recommendation that they were given.

When I asked why the doctor prescribed such a bizarre dietary change the patient replied that the antioxidants from blueberries can interfere with the chemotherapy and radiation. Although I was happy to hear that this doctor was offering dietary advice, unfortunately this advice is not accurate. There is no evidence to suggest that antioxidants from natural sources are dangerous during chemotherapy or radiation. In fact, virtually all of the literature clearly states the opposite which is that it is very beneficial to get antioxidants from natural sources. By consuming antioxidant rich foods patients have less side effects during chemotherapy and radiation. Many studies have also clearly demonstrated that these foods do not interfere with the effectiveness of these conventional therapies2,3,4,5,6,7.

It is interesting to note that of all the foods in the world this doctor only picked one item: blueberries. I am not sure of the rationale with this recommendation because there are countless foods that have antioxidant properties. Although blueberries are commonly associated with being antioxidants they are not very potent antioxidants when compared to other common foods. The antioxidant capacity of a food is measured by a lab test which determines the ability of that food to neutralize free radicals. This is commonly known as the Oxygen Radical Absorbance Capacity (ORAC) and a quick google search will clearly demonstrate that blueberries do not even make the top 50 for antioxidant capacity. These values are based on biological samples in vitro and it is not clear how significant these values are in the human body. What is clear, is that these values are a measure of the antioxidant capacity of these foods.

Depending on which source you look at blueberries have a ORAC value of approximately 6,500 which is not particularly high when compared to cinnamon which has an ORAC value of 265,000. In other words cinnamon is approximately 40 times stronger of an antioxidant compared to blueberries. Of course one could argue that you do not have as much cinnamon as blueberries, which is indeed true. However there are other foods consumed in comparable amounts to blueberries which have a significantly higher antioxidant capacity. Unsweetened cocoa powder has an ORAC value of 81,000 and baking chocolate has an ORAC value of 50,000. If you are having a food rich in chocolate then chances are you are consuming more antioxidants than if you are having blueberries1,8.

I am not suggesting that chocolate should be a primary source of antioxidants. I would certainly prefer that my patients get their antioxidants from blueberries rather than chocolate. There are many bioflavonoids in blueberries that are helpful in the context of cancer and the elevations in blood sugar from excessive chocolate consumption is not desirable in cancer patients. The point is that it is silly to single out one food as a antioxidant concern. The reality is that if you really want to cut antioxidants out of your diet it would involve much more than the elimination of blueberries. The advice of avoiding blueberries is confusing and it is simply not an evidence based dietary plan.

The bottom line is that these natural sources of antioxidants are very helpful in the context of cancer and there is no debate about this in the scientific community. The debate is around synthetic supplementation with high doses of antioxidants during chemotherapy and radiation. Natural sources are well established to be beneficial in these cases as they protect healthy cells without interfering with the effects of these conventional therapies5. So make sure you eat your blueberries and give your cells the nutrients that they need!

Blueberries are a great source of nutrients and they provide a balanced antioxidant support that is synergistic with chemotherapy and radiation. What is particularly interesting is that wild blueberries are much more effective at neutralizing free radicals when compared to cultivated blueberries. Depending on which measurements you use, in some cases the wild blueberries have almost double the antioxidant capacity!

If you are undergoing chemotherapy or radiation make sure that you contact a Naturopathic Doctor to develop an evidence based treatment plan that can support you through these therapies. During chemotherapy or radiation your cells are under a significant amount of stress and it is essential that you adequately supply your cells with the necessary nutrients. Diet is an important component of any integrative cancer therapy.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hons) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Authorhttp://www.dreamhealer.com

His clinical focus is Naturopathic Oncology and he currently practices as at Yaletown Naturopathic Clinic in Vancouver, BC. http://www.yaletownnaturopathic.com

References:

1) Haytowitz, David B., and Seema Bhagwat. “USDA database for the oxygen radical absorbance capacity (ORAC) of selected foods, Release 2.” US Department of Agriculture(2010).

2) Moss, Ralph W. “Should patients undergoing chemotherapy and radiotherapy be prescribed antioxidants?.” Integrative cancer therapies 5.1 (2006): 63-82.

3) Simone, Charles B., et al. “Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 1.”Alternative therapies in health and medicine 13.1 (2007): 22.

4) Drisko, Jeanne A., Julia Chapman, and Verda J. Hunter. “The use of antioxidant therapies during chemotherapy.” Gynecologic oncology 88.3 (2003): 434-439.

5) Moss, Ralph W. “Do antioxidants interfere with radiation therapy for cancer?.” Integrative cancer therapies 6.3 (2007): 281-292.

6) Conklin, Kenneth A. “Cancer chemotherapy and antioxidants.” The Journal of nutrition134.11 (2004): 3201S-3204S.

7) Block, Keith I., et al. “Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials.” International Journal of Cancer 123.6 (2008): 1227-1239.

8) Vertuani, Silvia, et al. “Evaluation of Antiradical Activity of Different Cocoa and Chocolate Products: Relation with Lipid and Protein Composition.” Journal of medicinal food 17.4 (2014): 512-516.

How does Artesunate kill cancer? April 20, 2015

Posted by Dreamhealer in Alternative medicine, Cancer, Naturopathy.
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Close up of someone holding a plant in his hand

Artesunate is a drug that was initially designed for combating malaria, however, recently it has shown great promise as a cancer therapy1,2,3. It has been used in combination with some chemotherapies to improve outcomes in advanced cancer patients5. When fighting cancer it is important to use every tool at your disposal to weaken the cancer and strengthen your own cells. Artesunate is another weapon in the arsenal of natural remedies that can make a significant difference in the fight against cancer.

The mechanism of action for artesunate in the context of cancer therapy is very well defined. Cancer cells have a tendency to absorb iron at high levels and this is thought to accelerate the mutation rate within these cells. Iron reacts with oxygen to form free radicals, which are reactive molecules that damage DNA. In normal cells this reaction is a problem; in cancer cells it allows them to mutate and develop resistance to therapies. Artesunate activates mitochondrial apoptosis by iron catalyzed lysosomal reactive oxygen species production4. In other words, this drug will use the iron within the cancer cells against them.

Preliminary data from Bastyr Integrative Oncology Research Center indicates that IV Vitamin C (IVC) in conjunction with IV Artesunate makes a substantial difference in advanced cancers. IV Artesunate is often administered right before high dose IV vitamin C and there is evidence that these therapies work synergistically together. In patients with Stage 4 Breast cancer, after 1 year the group that received no IV Vitamin C and IV Artesunate had a 74% survival rate. Compared to the IV Vitamin C and IV Artesunate group which had a 90% survival rate after 1 year. By year 2 the results were even more significant as the group that did not receive treatment had a 68% survival rate compared to 90% in the treatment group. It is also important to note that no adverse events were associated with this treatment.

These preliminary results strongly suggest that high dose IV Vitamin C and IV artesunate improves survival in stage 4 breast cancer patients. Evidence is growing that the use of this therapy is effective for a wide range of cancers. Research has shown that Artesunate can increase quality of life in addition to improving survival rates. Just like any other cancer therapy, it is important that it is used under the supervision of a experienced Naturopathic Physician who focuses in oncology. At my clinic I regularly see patients improve significantly when they use this therapy as part of a comprehensive integrative cancer therapy.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

 

References:

1) MIYACHI, HAYATO, and CHRISTOPHER R. CHITAMBAR. “The anti-malarial artesunate is also active against cancer.” International journal of oncology 18 (2001): 767-773.

2) Michaelis, Martin, et al. “Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.” Biochemical pharmacology 79.2 (2010): 130-136.

3) Du, Ji-Hui, et al. “Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivo.” Cancer chemotherapy and pharmacology 65.5 (2010): 895-902.

4) Efferth, Thomas, et al. “Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron.” Free Radical Biology and Medicine 37.7 (2004): 998-1009.

5) Zhang, Z. Y., et al. “[Artesunate combined with vinorelbine plus cisplatin in treatment of advanced non-small cell lung cancer: a randomized controlled trial].” Zhong xi yi jie he xue bao= Journal of Chinese integrative medicine 6.2 (2008): 134-138.

8th Annual Cancer Prevention and Healing Event April 13, 2015

Posted by Dreamhealer in Alternative medicine, Cancer, Healing.
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Dr. Adam McLeod will be holding a special Integrative Cancer Care and Prevention Lecture on Saturday, June 6th from 12PM to 3PM. Don’t miss out! You can purchase your tickets here.

8th annual cancer prevention and healing event

Fasting Before Chemotherapy March 30, 2015

Posted by Dreamhealer in Alternative medicine, Cancer, Chemotherapy.
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Written By: Dr. Adam McLeod, ND, BSc

There has been a major movement lately for cancer patients to fast before and after an infusion of chemotherapy. When first hearing this, it sounds dangerous to encourage a patient to fast when their body is already stressed with chemotherapy. Fasting before chemotherapy has been used safely in several clinical trials1,4. It turns out that there is a significant amount of scientific data to support this therapy when the patient is properly supervised. This is a very interesting shift in thinking because the conventional approach in the past has been encouraging patients to get as many nutrients into their body as possible.

There are a number of metabolic reasons why fasting may increase the effectiveness of chemotherapy while reducing the side effects2,3. Fasting triggers normal cells to enter into a protective mode. They rapidly become more efficient and this triggers a reduction in glucose and IGF-1 levels by more than 50%3. This rapid metabolic shift would be very difficult to achieve even with a very potent mixture of drugs. Cancer cells are unable to shift into this protective mode and this makes them more vulnerable to the chemotherapy than normal cells5. This is referred to as differential protection and it has the potential to transform conventional cancer care.

The length of fasting before chemotherapy varies significantly depending on which study that you look at. The most commonly recommended fasting period is 48 hours before chemotherapy and this continues until 24 hours after the chemotherapy infusion. During this fasting period ideally the patient should only have water. It should be as close to complete fasting as possible.

Although it is clearly uncomfortable not eating for a total of 72 hours, the research is indicating that this is a worthwhile sacrifice. The discomfort from hunger will actually decrease the severity of the side effects from the chemotherapy. It is also important to keep in mind that this starvation state is triggering a powerful metabolic shift in your cells that protects your cells while making the cancer cells more vulnerable to the chemotherapy.

As fasting before chemotherapy is further researched it is likely that other mechanisms will be discovered that explain this differential protection. Even without a fully defined biochemical mechanism for this protection, it is clear that fasting does make a substantial difference. Do not implement a fasting protocol before chemotherapy without the supervision of a qualified health professional. It is essential that you are monitored during this process because fasting is not safe for everyone.

If you are currently doing chemotherapy make sure that you contact a Naturopathic Physicianwho focuses on oncology. There are many different naturopathic therapies which not only increase the effectiveness of the chemotherapy but they can act to reduce side effects from the chemotherapy. These natural approaches are safe to use with chemotherapy when they are used under the supervision of an experienced Naturopathic doctor. A Naturopathic Doctor that works with oncology will take the time to look at your case and help you effectively integrate these approaches into your program.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

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