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Low Dose Naltrexone and Cancer February 23, 2015

Posted by Dreamhealer in Cancer, Naturopathic Medicine, Naturopathy.
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Written by: Dr. Adam McLeod, ND, BSc

Naltrexone is typically used for patients with opioid or alcohol dependence. It is a molecule that powerfully counteracts the effects of opioids. At lower doses this drug can be used with cancer patients to help balance the immune system and inhibit the growth of cancer1. There are many well documented cases in the scientific literature of patients surviving years longer than expected after using low dose naltrexone (LDN)2,4. This therapy is rapidly becoming a mainstream therapy as more research accumulates supporting its use in cancer.

The mechanism of the anti-cancer properties of LDN are poorly defined. It is thought that the LDN targets the opioid growth factor receptor pathway to inhibit cell proliferation in cancerous cells5. There is also evidence to suggest that at these lower doses the immune system is modulated in a way that is beneficial to fighting cancer3. These positive changes in the immune system from LDN have also been shown to make a positive difference in patients with Multiple Sclerosis and HIV. The bottom line is that when used appropriately it can be an effective component of a integrative cancer therapy program.

When LDN is used in conjunction with alpha lipoic acid (ALA) it can be a very potent therapy for pancreatic cancer. There are a number of case studies where patients with metastatic pancreatic cancer have survived many years longer than expected using only this therapy2,4. It is very commonly used with lymphoma when patients are not on opioids for pain management. There are also several studies that support the use of LDN with ovarian cancer and preliminary research indicates that it works synergistically with the chemotherapy cis-platin1.

The side effects from naltrexone are minimal when taken at low doses. Often cancer patients will take 3mg before bed and sometimes this results in vivid dreams. The most common side effect is loose stools which is not surprising given the mechanism of the drug. Opioid medication often causes extreme constipation due to stimulation of the opioid receptors. Low dose naltrexone does the opposite by inhibiting the opioid receptors and loose stools can be a consequence of this. A significant number of cancer patients tend to be constipated due to the medications and as a result the “laxative effect” of the LDN is not a serious concern.

It is important to recognize that this therapy is not for everyone. Many cancer patients are treated with opioids for pain management. Given that this drug acts as a opioid antagonist, it is not indicated for patients on opioid medication such as morphine. It would directly counteract the effects of this important pain medication. When LDN is used in the appropriate cellular context it can be an effective component of an integrative cancer therapy. A Naturopathic doctor who focuses in oncology will go through your entire case history to determine if this treatment is indicated. Contact your local naturopathic doctor to see if this therapy is right for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Authorhttp://www.dreamhealer.com

He currently practices at his clinic in Vancouver, BC where he focuses on integrative oncology.http://www.yaletownnaturopathic.com

References:

1) Donahue, Renee N., Patricia J. McLaughlin, and Ian S. Zagon. “Low-dose naltrexone suppresses ovarian cancer and exhibits enhanced inhibition in combination with cisplatin.”Experimental Biology and Medicine 236.7 (2011): 883-895.

2) Berkson, Burton M., Daniel M. Rubin, and Arthur J. Berkson. “The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous α-lipoic acid/low-dose naltrexone protocol.” Integrative cancer therapies 5.1 (2006): 83-89.

3) Brown, Norman, and Jaak Panksepp. “Low-dose naltrexone for disease prevention and quality of life.” Medical hypotheses 72.3 (2009): 333-337.

4) Berkson, Burton M., Daniel M. Rubin, and Arthur J. Berkson. “Revisiting the ALA/N (α-Lipoic Acid/Low-Dose Naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases.” Integrative cancer therapies 8.4 (2009): 416-422.

5) Donahue, Renee N., Patricia J. McLaughlin, and Ian S. Zagon. “Low-dose naltrexone targets the opioid growth factor–opioid growth factor receptor pathway to inhibit cell proliferation: mechanistic evidence from a tissue culture model.” Experimental Biology and Medicine 236.9 (2011): 1036-1050.

The Importance of Energy Medicine January 27, 2015

Posted by Dreamhealer in Acupuncture.
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Every living organism has an energy field that is in constant interaction with other fields of energy belonging to other people and the environment itself. Energy healing involves the use of focused intentions which can help to re-pattern the patient’s energy field in order to accelerate healing of the body, mind and spirit. Energy medicine can be used effectively in conjunction with any medical therapy.

If a patient suffers from a disruption of their energy field, this can lead to disharmony of the physical body and the development of disease. Those disruptions can be addressed by proactively working with the energy. The goal of energy medicine is to use the energetic interaction between the practitioner and the patient in a purposeful manner to restore balance to the patient’s disrupted energy field.

Energy medicine works well for anxiety, improving muscle relaxation, aiding in stress reduction, chronic pain and promoting a sense of wellbeing. Research is beginning to show that energy healing is an effective tool that provides encourages healing on many different levels including the physical, emotional, mental, and spiritual.

Contact us today too book an appointment to begin your healing journey with the Yaletown Naturopathic Clinic. Call us at 604-235-8068 or visit our website http://www.yaletownnaturopathicclinic.com

The Dangers of DHEA January 12, 2015

Posted by Dreamhealer in Anti-Aging, Breast Cancer, Cancer, Naturopathic Medicine.
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Best Vancouver Naturopath

Written by Dr. Adam McLeod, BSc, ND

DHEA (Dehydroepiandrosterone) is often described as a wonder drug that is used by patients interested in its anti-aging effects. As we age the levels of DHEA in the blood start to decrease so the logic was that if patients were given this hormone then they would be able to partially reverse the aging process. There is evidence to suggest that indeed it improves many of the characteristics that we associate with aging.

Supplementation with DHEA is not safe for everyone as it is strongly associated with an increased risk of developing breast cancer1,2. In response to this risk, supplement companies began to produce a molecule called 7-keto DHEA, which is a metabolite of DHEA. This was considered a safer alternative to DHEA because it does not break down into estrogen or testosterone4. It is true that when patients take 7-keto DHEA there is no statistically significant increase in hormone levels but this does not make it safe to use with breast cancer.

I have personally seen several patients with active estrogen positive breast cancer who were prescribed 7-keto DHEA by a medical doctor. This is a dangerous combination and it is reckless to prescribe this medication in this clinical situation. 7-keto DHEA is not safe for any patient with estrogen positive breast cancer. There are a number of obvious biochemical reasons for this contraindication. First of all there are absolutely no studies which indicate that this is safe with estrogen positive breast cancer. Secondly, just because the estrogen levels are not elevated does not mean that the estrogen receptor is not being stimulated.

Normally the receptors on the surface of a cell are only stimulated by a few specific molecules. The estrogen receptors are notoriously promiscuous. What this means is that they are stimulated by many different molecules as well as estrogen. One of those molecules is 7-keto DHEA. In other words, even though patients do not have elevations in estrogen levels the estrogen receptors are being directly stimulated by the 7-keto DHEA3. As far as the cancer cells are concerned, they will act as if they are being stimulated by estrogen even though the actual levels of estrogen remain unchanged.

In one study it was conclusively shown that 7-keto DHEA (aka 7-oxo DHEA) is a low affinity ligand activator of estrogen receptors. The estrogen activity in these cancer cell lines were significantly elevated compared to the controls. In this same study, the cancer cells (MCF-7 breast cancer cells) that were treated with 7-keto DHEA grew much faster than the controls. This simple study certainly raises concern about the use of this supplement in cancer patients. It is clearly misleading to state that 7-keto DHEA has all the positive effects of DHEA without any of the negative effects. This is simply not how our cells operate on the biochemical level.

Another obvious concern is that 7-keto DHEA is essentially structurally identical to DHEA. This means that its overall shape is so similar that it will stimulate estrogen receptors the same as if it was DHEA. The estrogen receptors on cancer cells cannot tell the difference between 7-keto DHEA and DHEA. As far as the cancer is concerned it is the same thing. Of course the DHEA will not stimulate these receptors as strongly as estrogen but they still increase the activity which is the complete opposite of what you want to do with estrogen positive breast cancer. Conventional cancer therapies work very hard to reduce estrogen activity as much as possible because this activity acts as a signal for these cancer cells to grow5.

It is important that more patients become aware of this serious concern because it is difficult to sift through the mountains of information on the web. Unfortunately, there are still doctors that are prescribing this medication to estrogen positive breast cancer patients. The simple explanation that estrogen levels are unaffected does not mean that it is safe. Biology is much more complex than simply monitoring the level of a few arbitrary hormones in the blood. There is significant cross talk between these different pathways in cells and this well understood biological concept also applies to the clinical setting.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author http://www.dreamhealer.com

He currently practices at his clinic, Yaletown Naturopathic Clinic, in Vancouver, BC where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References:

1) Tworoger, S. S.; Missmer, S. A.; Eliassen, A. H. et al. (2006). “The association of plasma DHEA and DHEA sulfate with breast cancer risk in predominantly premenopausal women”. Cancer Epidemiol. Biomarkers Prev. 15 (5): 967–71.

2) Key, T.; Appleby, P.; Barnes, I.; Reeves, G. (2002). “Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies”. J. Natl. Cancer Inst. 94 (8): 606–16.

3) Michael Miller, Kristy K., et al. “DHEA metabolites activate estrogen receptors alpha and beta.” Steroids 78.1 (2013): 15-25.

4) Lardy, H; Kneer N, Wei Y, Partridge B, Marwah P (1998). “Ergosteroids II: Biologically Active Metabolites and Synthetic Derivatives of Dehydroepiandrosterone”. Steroids 63 (3): 158–165.

5) Janni W, Hepp P. Adjuvant aromatase inhibitor therapy: Outcomes and safety. Cancer Treat Rev. 2010; 36:249–261.

Cancer: Know your enemy December 4, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Naturopathic Medicine.
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Cancer;know your enemy

By: Dr. Adam McLeod, ND, BSc

Chemotherapy is an effective tool at killing cancer cells when it is used appropriately. The biggest challenge is knowing which drug is best suited for an individual’s cancer. Over the years we have learned that certain cancers tend to be more vulnerable to specific chemotherapies. This has resulted in specific protocols being assigned to patients in a “cookie cutter system”. For example, if you have hodgkins lymphoma you are given ABVD1. If you have non-hodgkins lymphoma you are given CHOP2. This model is currently the standard of care with cancer treatment but it is clear that this is not the most effective way to treat cancer.

It is true that certain cancers tend to be susceptible to certain chemotherapies but these generalizations are not universally correct. There is an incredible degree of variation between cancer cells in different people. Genetic variations are significant even between different cells within one tumour in an individual3. In fact, very often there is a protocol different than the standard chemotherapy regimen that would be more effective4. Unless tests are done there is no way of knowing which protocol will be the most effective. It is essential to run these tests first and have a clear rationale for the chemotherapy protocol rather than testing on the patient through trial and error.

There is no question that targeted cancer therapies are the future of oncology. It is very important for patients to realize that we already have the ability to do this. Personalized cancer therapy is available but it is rarely encouraged by oncologists due to the costs. Although these tests are often not covered, they can be done privately for approximately $4000.00.

The older chemotherapy protocols involve using extremely toxic compounds that target any cell which is growing rapidly. In recent years there have been major advances in drugs that target specific pathways in cancer cells5. Before using these targeted drugs effectively it is essential to know which targets the cancer cells are vulnerable to.

When a surgery or biopsy is performed on a cancerous mass it is essential that the sample be sent to a lab that runs these personalized genomic tests. The cancerous cells will be tested against hundreds of different types of chemotherapies and clear evidence will be obtained about which drugs the cancer is actually susceptible to. This vulnerability of the cancer is determined by an actual test on the cells rather than making generalizations based on the type of cancer. As these tests become more affordable it will inevitably become the future standard of care because it is so much more effective than the current standard model.

This is something that patients need to ask for before the surgery. You cannot ask for it to be done afterwards because the cells will not be adequately preserved. This service is rarely offered to patients and few are even aware that this is an option. You need to specifically ask for the cells to be sent to a lab that runs these tests.

Personalized cancer therapy gives patients many additional treatment options. If they do not tolerate the initial chemotherapy regiment well or if the cancer becomes resistant to the first line therapy, then there is a potential “Plan B” that is effective based on molecular evidence. By running this test it will give your oncologist data that justifies the use of a protocol, which may deviate from the current standard of care. The data will give a distinct molecular profile of the cancer that allows a customized treatment plan to be developed for you.

If this customized approach is something you are interested in doing make sure you speak to your oncologist. Any naturopathic doctor who works with oncology on a regular basis will also be familiar with these tests. Contact your local naturopathic doctor to see if this test is right for you.

Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author http://www.dreamhealer.com

He currently practices at his clinic in Vancouver, BC where he focuses on integrative oncology.http://www.yaletownnaturopathic.com

References:

1) Bonadonna G, Zucali R, Monfardini S, De Lena M, Uslenghi C (1975). “Combination chemotherapy of Hodgkin’s disease with adriamycin, bleomycin, vinblastine, and imidazole carboxamide versus MOPP.”. Cancer 36 (1): 252–9

2) Fisher RI, Gaynor ER, Dahlberg S, Oken MM, Grogan TM, Mize EM, Glick JH, Coltman CA Jr, Miller TP (1993). “Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin’s lymphoma.”. N Engl J Med 328 (14): 1002–6.

3) Ross, Douglas T., et al. “Systematic variation in gene expression patterns in human cancer cell lines.” Nature genetics 24.3 (2000): 227-235.

4) Strickland, Stephen A., et al. “Correlation of the microculture-kinetic drug-induced apoptosis assay with patient outcomes in initial treatment of adult acute myelocytic leukemia.” Leukemia & lymphoma 54.3 (2013): 528-534.

5) McDermott, Ultan, and Jeff Settleman. “Personalized cancer therapy with selective kinase inhibitors: an emerging paradigm in medical oncology.” Journal of Clinical Oncology 27.33 (2009): 5650-5659.

Stress causes Cancer November 28, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Naturopathic Medicine, stress.
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By: Dr. Adam McLeod , ND

Everyday in my practice I see cancer patients who feel that there is a very strong emotional source to their cancer. Patients will often be able to directly connect the formation of their cancer with a stressful event in their life. This is not an imaginary connection, there are biological reasons why emotional stress can trigger the formation of cancer.

Stress can cause cancer. It is important to point out that this is not a hypothetical concept. This is a statement that is well supported by scientific evidence1,2,3. The link between cancer and stress is well established and is not debated by the scientific community. Many people are not aware how significant this connection is and often this connection is disregarded by medical doctors, despite the body of evidence.

There are a number of different biological reasons why stress inhibits the immune system in its fight against cancer. Natural Killer cells are essential in resisting the progression and metastatic spread of tumours once they have developed4. It is well documented that the activity of these crucial cells decreases significantly with stress5. In other words, the cells that patrol your body looking for abnormal cells are less active when you are under stress.

A key component to the development of cancer is mutations in the DNA. A number of well controlled studies have shown that cells are less efficient at repairing DNA damage when a patient is stressed. Patients who are more depressed show significantly poorer repair of damaged DNA compared to their less depressed counterparts6. This is significant because the mutations that drive the initiation and development of cancer are not repaired as effectively in a patient under stressful conditions.

In addition to the effects of stress on DNA repair, additional research has shown that apoptosis is inhibited by stress7. When a cell begins to turn cancerous, the cell will undergo what is called programmed cell death (also known as apoptosis). In other words, when a cell begins to get too abnormal it will commit suicide. This is one of the most fundamental defense mechanisms that our body has to fight the development of cancer. When this process is inhibited, clearly the risk for developing cancer is higher.

The good news is that you can help your body fight cancer by reducing stress and focusing your intentions on healing. One of the most comprehensive intervention studies in cancer research evaluated the effects of stress management techniques, such as relaxation on cancer recurrence following removal of malignant melanoma9. Not only did the relaxed group experience reduced psychological distress, they also had more active immune systems. A 6-year follow up of these patients showed a trend toward greater recurrence and higher mortality rates in the control group, compared to the relaxed group8. The bottom line is that patients who focus on reducing stress and focusing their minds on healing not only have a better prognosis, they also have lower rates of developing cancer in the first place. Given what we know about the connection between immune function and stress, this conclusion should not be surprising.

When fighting cancer it is important to use every tool at your disposal to increase the chances of a successful recovery. The immune system must be strong to fight off any serious disease. Our minds can dramatically influence how our cells respond to stress and this is intimately connected to the function of the immune system. We all need to take control of our health and use this connection to our advantage. By reducing stress and focusing our minds on healing we will live longer and happier lives10. This is a powerful tool that we can all use to our advantage.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology.http://www.yaletownnaturopathic.com

References:

1)    Bovberj DH. Physchoneuroimmunology: Implications for oncology? Cancer 1991; 67: 828-832.

2)    Spiegel D, Kato PM. Psychosocial influences on cancer incidence and progression. Harvard Rev Psychiatry 1996; 4: 10-26.

3)    Andersen BL, Farrar WB, Golden-Kreutz D et al. Stress and immune responses after surgical treatment for regional breast cancer. J Natl Cancer Inst 1998; 90: 30-36.

4)    Herberman RB. Immunotherapy. In Lenhard RE Jr, Osteen RT, Gansler T (eds): Clinical Oncology. Atlanta, GA: American Cancer Society 2001; 215-223.

5)    Zorrilla EP, Luborsky L, MacKay JR et al. The relationship of depression and stressors to immunological assays: A meta-analytic review. Brain Behav Immun 2001; 15: 199-226.

6)    Kiecolt-Glaser JK, Stephen RE, Lipetz PD et al. Distress and DNA repair in human lymphocytes. J Behav Med 1985; 8: 311-320.

7)    Tomei LD, Kiecolt-Glaser JK, Kennedy S, Glaser R. Psychological stress and phorbol ester inhibition of radiation-induced apoptosis in human PBLs. Psychiatry Res 1990; 33: 59-71.

8)    Fawzy IF, Fawzy NW, Hyun CS et al. Malignant melanoma: effects of an early structured psychiatric intervention, coping and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry 1993; 50: 681-689.

9)    Fawnzy IF, Kemeny ME, Fawzy NW et al. A structured psychiatric intervention for cancer patients. Arch Gen Psychiatry 1990; 47: 729-735.

10)  Veenhoven et al. Healthy happiness: effects of happiness on physical health and the consequences for preventative health care. Journal of Happiness Studies, 2008; 9(3): 449.

Naturopathic Medicine and Cancer November 18, 2014

Posted by Dreamhealer in Cancer, Naturopathic Medicine.
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By: Dr. Adam McLeod ND, BSc (Hon)

Naturopathic medicine has a wide range of tools that can be used in conjunction with conventional medicine to effectively treat cancer. Many people have this underlying assumption that naturopathic treatments are not “evidence based” because otherwise their oncologist would have recommended them. The truth is that many of these therapies are extremely well documented by scientific studies and the mainstream scientific community does not dispute their effectiveness. The bottom line is that cancer patients do better when they have an integrative health care team and Naturopathic doctors are an integral part of this team.

When dealing with a complex condition such as cancer it is very important to thoroughly review the entire health history of the patient, not just the diagnosis of cancer. It is essential that as physicians we actually take the time to listen to what the patient is saying. This allows us to develop a custom treatment plan for that individual which addresses the unique circumstances of that patient. Naturopathic doctors are experts at taking the time to listen to the patient and developing a treatment plan for that unique patient.

Chemotherapy and radiation are effective therapies and often it is a race between the death of the cancer cells and the death of healthy cells. Making sure the healthy cells are supplied with adequate nutrients allows patients to endure these harsh therapies with fewer side effects. Very often patients who are adequately supported with the appropriate nutrition and supplements will be able to tolerate additional rounds of chemotherapy and radiation. Ultimately if healthy cells are more likely to survive, this helps stack the odds against cancer cells.

Patients are often reluctant to take any supplements during chemotherapy and radiation because of potential interactions. This is a legitimate concern because there are many negative interactions if the wrong supplement is used. Any Naturopathic Doctor who regularly works with cancer is well aware of these interactions. When the appropriate supplements are used there are profound benefits to cancer patients. These supplements are well supported by scientific evidence and they have been consistently demonstrated to be safe when used in the right context. This is why the blanket statement of “avoid all supplements” is simply incorrect. It is absolutely essential that you have professional guidance from an experienced Naturopathic Doctor when you are picking supplements.

The mainstream medical community is slowly becoming more open to collaborating with Naturopathic Doctors because the evidence for the benefits of an integrative approach to cancer care can no longer be ignored. For years Naturopathic Doctors have been using high dose IV Vitamin C as a cancer therapy and traditional medical doctors considered it to be a nonsense therapy. Recently they have changed their attitude and oncologists are jumping on to the Vitamin C bandwagon. There is no doubt that when used appropriately this can be an effective integrative cancer therapy.

Patients who undergo this therapy tend to experience less significant side effects from the chemotherapy. IV Vitamin C can vastly improve quality of life by increasing appetite, raising platelet counts, easing fatigue and reducing pain. When patients are supported by the appropriate nutrients and supplements, the side effects from chemotherapy are less intense. Studies consistently show that at these high doses, Vitamin C is toxic to cancer cells while protecting healthy cells from the adverse effects of chemotherapy. The evidence indicates that IV Vitamin C is effective when used in conjunction with chemotherapy rather than as a stand-alone therapy. This is just one example of many different effective natural cancer therapies available. There is much more to integrative oncology than simply IV Vitamin C!

There is no question that there is often a strong emotional component to cancer and this must be addressed for optimal healing to take place. Patients will often be able to directly connect the formation of their cancer with a stressful event in their life. This is not an imaginary connection; there are biological reasons why emotional stress can trigger the formation of cancer. Stress can cause cancer. It is important to point out that this is not a hypothetical concept. This is a statement that is well supported by scientific evidence. The link between cancer and stress is well established and is not debated by the scientific community. Many people are not aware how significant this connection is as medical doctors often disregard this connection despite the body of evidence. Naturopathic doctors not only address the physical components of health, they will also take the time to address the emotional and spiritual components that simply cannot be ignored in patients with cancer.

If you know someone with cancer, make sure you let them know about the potential benefits of seeing a Naturopathic Doctor who focuses on cancer. There are so many amazing tools that Naturopathic medicine has to offer and the public needs to be aware that these therapies exist and that they are effective!

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular Biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology.

http://www.yaletownnaturopathic.com

Mistletoe the Parasite October 1, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Health.
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Mistletoe is a parasitic plant that directly derives almost all of its nutrition from other flowering plants. By parasitizing other plants, they have a competitive advantage over many other forms of life because they do not have to compete in soil for their water and nutrient needs. This description of mistletoe sounds surprisingly similar to how cancer operates. When you look at mistletoe growing on a tree it looks very much like a tumour. Cancer gets all of its nutrition from other cells within the human body and it has a competitive advantage because it does not abide by the same rules as other cells in the body.

It turns out the mistletoe can be used to effectively treat cancer, even in advanced cases1,2,3. In North America this is often considered a “fringe treatment” yet if you go to Germany this is a mainstream therapy that is well established by the scientific community. The use of mistletoe dramatically reduces the side effects associated with chemotherapy and radiation. The effects are so dramatic that some countries have already made this the standard of care for cancer treatment. The use of mistletoe as the new standard of care was of huge financial benefit to these countries because of the significant decrease in complications from chemotherapy and radiation.

Although there are several different ways to administer mistletoe, the most common is regular subcutaneous injections. This involves the use of small insulin needles and injecting the mistletoe just under the skin. After injecting the mistletoe lectins the immune system immediately begins to attack the injected fluid resulting in a small red rash around the injection site. This immune activation is an excellent outcome in the context of cancer. By activating the immune system at the site of injection it consequently activates the immune system in the entire body.

Mistletoe has been shown to stimulate increases in the number and the activity of several types of white blood cells4. Immune-system-enhancing cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor -alpha, are released by white blood cells after exposure to mistletoeextracts5,6. Other evidence suggests that mistletoe exerts its cytotoxic effects by interfering with protein synthesis in target cells and by inducing apoptosis7.

Just like any cancer therapy it is essential that it is used in the right context. When this therapy is used there will initially be a swelling of the tumour, this is a consequence of the immune activation. If there are any detectable masses contained within the skull, then clearly swelling is not desirable. Mistletoe therapy is contraindicated in patients that have any detectable mass in the brain. It also must be used with caution on patients that are are cachexic and malnourished. The sudden release of cytokines associated with immune activation can worsen the malnourished state.

Mistletoe therapy only costs approximately $250 dollars per month and it can be used in conjunction with other medical therapies. I regularly use mistletoe with my patients at the clinic and it is an effective cancer therapy when used appropriately. On a regular basis I see patients improve when they use this therapy as part of a comprehensive integrative cancer therapy. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References:

1. Mistletoe. In: Murray MT: The Healing Power of Herbs. Roseville, Calif: Prima Publishing, 1995, pp 253-9.

2. Samtleben R, Hajto T, Hostanska K, et al.: Mistletoe lectins as immunostimulants (chemistry, pharmacology and clinic). In: Wagner H, ed.: Immunomodulatory Agents from Plants. Basel, Switzerland: Birkhauser Verlag, 1999, pp 223-41.

3. Hajto T, Lanzrein C: Natural killer and antibody-dependent cell-mediated cytotoxicity activities and large granular lymphocyte frequencies in Viscum album-treated breast cancer patients. Oncology 43 (2): 93-7, 1986.

4. Büssing A, Regnery A, Schweizer K: Effects of Viscum album L. on cyclophosphamide-treated peripheral blood mononuclear cells in vitro: sister chromatid exchanges and activation/proliferation marker expression. Cancer Lett 94 (2): 199-205, 1995.

5. Hajto T: Immunomodulatory effects of iscador: a Viscum album preparation. Oncology 43 (Suppl 1): 51-65, 1986.

6. Hajto T, Hostanska K, Frei K, et al.: Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 50 (11): 3322-6, 1990.

7. Mengs U, Schwarz T, Bulitta M, et al.: Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice. Anticancer Res 20 (5B): 3565-8, 2000 Sep- Oct.

Is the Alkaline Diet an Effective Cancer Treatment? September 11, 2014

Posted by Dreamhealer in Healing.
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Cancer food

Every day I see cancer patients who are drinking alkaline water and focusing a significant amount of their time and energy on alkaline foods. Is this an effective cure for cancer? The short answer is no and any observed positive effects have nothing to do with the foods being alkaline. Let me explain why this is.

In the early 20th century it was observed that cancer cells could not grow in alkaline environments. There are a number of metabolic reasons why this is and this principle is very effective in a petri dish. The problem is that this theory simply does not apply to our bodies. The pH is a measure of how acid or basic a liquid is. You cannot change the pH of your blood enough to influence cancer. To understand why, you need to look at the biochemistry of the blood.

Our blood is buffered which means that it is absolutely full of molecules that make sure there are no variations in the pH of the blood. The body spends a substantial amount of energy keeping the pH of the blood with in a very narrow range. Every single protein in your entire body is designed to work at a very specific pH. If there is any deviation from this optimal pH then the protein ceases to function properly. In other words, if you were able to make your blood significantly more basic it would very quickly result in kidney failure, respiratory failure and ultimately death. Our cells have been adapting to a very narrow pH range for millions of years and there are many metabolic reasons for this. When you drink alkaline water and eat alkaline foods it does not make your blood alkaline.

Any positive studies relating to the alkaline diet have nothing to do with the foods being alkaline. When you look at the list of “alkaline foods” it consists mostly of fresh fruit, vegetables, nuts and legumes with very small amounts of meat. These are all very healthy foods that are rich in nutrients. The high nutrient content is completely unrelated to the alkaline nature of these foods.

When designing an ideal diet plan for cancer patients the first goal is making sure they are getting adequate nutrients because the cells will have increased metabolic demands while fighting cancer. The second goal is making sure that they are avoiding foods that are rich in sugar. Very often this diet will consist of fresh fruits, vegetables, nuts and legumes. No one disputes that these foods are helpful when combating cancer but it is clear that this positive effect from these foods is not due to them being alkaline.

If you are fighting cancer it is essential that you have professional guidance with your diet. Before you make any dramatic changes contact a Naturopathic physician that works with oncology. A Naturopathic doctor that works with oncology will take the time to look at your case and will design a specific diet plan for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

By: Dr. Adam McLeod, ND, BSc

DCA and Cancer August 27, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Chemotherapy, Integrative Medicine, naturopathic, Naturopathic Medicine, Research.
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DCA and it's use in integrative oncology

DCA and it’s use in integrative oncology

By: Dr. Adam McLeod , ND, BSc

Several years ago there was a huge buzz in the media about Dichloroacetic Acid (DCA) and its use in cancer1. The public was outraged that DCA could be an effective cancer therapy and that the government showed little interest because DCA could not be patented. The drug companies ignored any evidence related to this therapy because without a patent it was simply not a profitable venture. Fortunately, some private researchers raised enough money to continue studies into this simple yet effective therapy.

DCA was initially used for lactic acidosis, a condition where the blood has high levels of lactic acid. The DCA inhibits the enzyme pyruvate dehydrogenase kinase which causes a major shift in metabolism from fermentation to oxidation in the mitochondria2. In other words, it forces the mitochondria in cells to become more active. This is relevant to cancer because the survival of cancer cells depends on the mitochondria being dormant. The mitochondria are capable of triggering cell death in abnormal or damaged cells. Cancer cells are grossly abnormal and they often depend on the mitochondria being inactive.

The ultimate goal of this therapy is to activate the mitochondria and allow them to trigger cell death in the abnormal cancerous cells. The DCA will certainly help to activate these pathways but it is essential that patients also exercise. By regularly doing aerobic exercise you are also stimulating the mitochondria. The excessive energetic demands during exercise trigger the mitochondria to be more active and burn oxygen. DCA when combined with exercise significantly increases the consumption of oxygen by the mitochondria which is an indication that the mitochondria are being further activated5.

It is essential for cancer patients (not just patients on DCA) to do aerobic exercise if they are physically able to. It does not matter what that type of exercise it is, just as long as it is a moderate aerobic exercise that you are able to do on a regular basis. There is an overwhelming body of evidence which clearly shows that cancer patients who regularly exercise simply do much better than those who do not. It is possible that this mitochondrial activation could be one of the reasons for this.

Most of the research seems to indicate that DCA is more effective for cancers that are localized in the nervous system3. Although it can be used for other types of cancer, it is less indicated for cancers that do not localize to the nervous system. A very common side effect from chemotherapy is neuropathy4 and DCA should be used with caution if there are any signs of neuropathy. There are no known drug interactions with DCA except for the drug Lasix which is a diuretic. Overall DCA is a very safe therapy and there are many studies that demonstrate the safety of this therapy.

The bottom line is that DCA is an effective therapy when used appropriately. It is not a cure on its own but DCA can be a major part of an effective and comprehensive integrative cancer treatment plan. It can be administered either orally or intravenously. The oral dose is typically 15-20mg/kg and it is cycled 2 weeks on followed by 1 week off. It is extremely important to have the appropriate neurological support during this therapy. DCA is known to cause significant neuropathy and you must be monitored by a physician who is experienced with the use of DCA. Common neurological support includes NAC, Thiamine (B1) and ALA. It is essential that you consult with a Naturopathic physician who focuses in oncology to know what neurological support is best suited for you.

A Naturopathic doctor that works with oncology will take the time to look at your case and will write you a prescription for DCA if it is truly indicated. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References

1) “Cheap, ‘safe’ drug kills most cancers”. New Scientist. 2007-01-17. Retrieved 2014-08-23.

2) Stacpoole PW (1989). “The pharmacology of dichloroacetate”. Metabolism 38 (11): 1124–1144. doi:10.1016/0026-0495(89)90051-6PMID 2554095

3) Michelakis E D, et al. Metabolic Modulation of Glioblastoma with Dichloriacetate. Sci Transl Med 12 May 2010: Vol. 2, Issue 31

4) Abramowski MC. Chemotherapy-Induced Neuropathic Pain. J of the Advanced Practitioner in Oncology. 2010;1:279-283.

5) Ludvik, Bernhard, et al. “Effects of dichloroacetate on exercise performance in healthy volunteers.” Pflügers Archiv 423.3-4 (1993): 251-254.

Fraud at the CDC uncovered, 340% increased risk of autism hidden from public August 25, 2014

Posted by Dreamhealer in Autism, Vaccines.
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vaccine causes autism

 

 

 

 

 

 

 

 

Story reported by cnn.com

A top researcher at the Centers for Disease Control and Prevention (CDC) played a key role in helping uncover data manipulation by the CDC. This fraud obscured a higher incidence of autism in African-American boys. The whistleblower, Dr. William Thompson, came forward after a Freedom of Information Act (FOIA) request for original data on an autism study was filed and these highly sensitive documents were received with the assistance of U.S. Representative Darrell Issa, Chairman of the House Oversight and Government Reform Committee. The CDC documents and discussions with the whistleblower reveal widespread manipulation of scientific data and top-down pressure on CDC scientists to suppress a causal link between the MMR vaccine and later autism diagnosis, particularly in a subset of African-American males who received their immunization “on-time” in accordance with the recommended CDC schedule.

 
The received documents from the CDC show that in 2003 a 340% increase in autism in African American boys related to the MMR vaccine was discovered and then hidden due to pressure from senior officials. The CDC researchers then recalculated their results by removing a population to get the results that were desired.

 
William Thompson has worked for the government agency for over a decade and confirmed that “the CDC knew about the relationship between the age of first MMR vaccine and autism incidence in African-American boys as early as 2003, but chose to cover it up.” He remarked “we’ve missed ten years of research because the CDC is so paralyzed right now by anything related to autism. They’re not doing what they should be doing because they’re afraid to look for things that might be associated.” He alleges criminal wrongdoing by his supervisors, and he expressed deep regret about his role in helping the CDC hide data.

 

Thompson’s revelations call into question the nine other studies cited by the CDC as evidence denying a link between vaccines and autism. They also have spurred a change.org petition to have the fraudulent study retracted from the Journal of Pediatrics, which published it in 2004.

 

A recently released memo from 2004 of Dr. Thompson expressing concerns to Dr. Gerberding, the head of the CDC at the time, about this problematic study has citizens upset. Does this mean Dr. Gerberding could have committed perjury during a congressional hearing? More investigation will be needed to know. A copy of the letter obtained under FOIA can be found here. http://www.naturalnews.com/images/CDC-Gerberding-Warning-Vaccines-Autism.jpg

 

Regardless many citizens view this as a deliberate malfeasance at the taxpayers’ expense have begun a social media blitz to inform others of this story as it unfolds. Using the Twitter hashtags #CDCwhistleblower and #CDCfraud. Parents are hoping to have the agency held accountable for its role in any cover-up and are demanding an investigation on whether Dr. Coleen Boyle also perjured herself in testimony before Congress when addressing concerns of a potential vaccine-autism link.

 

The US Department of Health Resources and Services Administration has already recognized autism as a secondary cause of vaccine injury as documented in the Update to the Vaccine Injury Table following the 2011 IOM report. They did reject Autism as a direct adverse effect of the MMR specifically, but in view of these revelations that may be revisited.

http://hrsa.gov/vaccinecompensation/iomreportupdate030812.pdf

More on this story from Yahoo News!
http://finance.yahoo.com/news/study-focus-autism-foundation-finds-133000584.html

 

The peer reviewed analysis of the original CDC data showing a 340% increase in autism in African American boys due to the MMR vaccine can be found here:

http://www.translationalneurodegeneration.com/content/3/1/16

CBS coverage can be found at: http://www.cbs46.com/story/26316561/focus-autism-releases-findings-on-2003-cdc-autism-study-higher-autism-rate-among-african-american-boys-receiving-mmr-shot-earlier-than-36-months#.U_noAOE5EeE.twitter

A 2012 peer reviewed research paper studying over 500,000 children found significant increase adverse effects after certain MMR vaccinations including a 22 Times increased risk of meningitis, 500% increase risk of febrile seizure, and other major side effects including a blood clotting disorder.

http://www.ncbi.nlm.nih.gov/pubmed/22336803

 

Article retrieved from: http://ireport.cnn.com/docs/DOC-1164794

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