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Green Tea and Cancer September 5, 2018

Posted by Dreamhealer in best vancouver naturopath, Cancer, cancer prevention, cancer therapy, Cancer Treatment, Chemotherapy, Healing, integrative cancer care, naturopath, naturopathic, Naturopathic Doctor, Naturopathic Medicine, naturpathic medicine.
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Written By: Dr. Adam McLeod, ND, BSc (Hons)

Green tea is a common beverage that can be found at any cafe yet it also has important therapeutic properties.

Epigallocatechin gallate (EGCG) is an extract from green tea that has shown great promise as an integrative cancer therapy. The mechanism of action is complicated because it interacts with multiple molecular pathways to inhibit the growth of cancerous cells. When cancer cells are exposed to EGCG, it triggers cell death by a variety of mechanisms1,2,3,4. Not only does it inhibit the growth of cancerous cells, but it also slows down the rate of metastasis.

Although there is a wide range of EGCG content in green tea, a strong tea has about 70mg per tea bag. The therapeutic doses for EGCG (particularly in the context of cancer) is a minimum of 1500mg per day. Which means you would have to have approximately 20 green teas per day to reach this dose. Obviously this is not practical as a long term treatment plan so the best way to get the appropriate doses is through pill form. If you enjoy having green tea then you can certainly continue to do so but you will not be significantly contributing to the therapeutic effect of the EGCG.

One important characteristic of EGCG is that it acts as an anti-angiogenic substance. Angiogenesis is the growth of new blood vessels into a developing tumour. This process is necessary when cancer cells are spreading because the smaller growths need a blood supply to sustain their rapid growth. Cancer cells will often secrete chemicals that trick the human body into growing blood vessels into the tumour. EGCG helps to inhibit this process by inhibiting the viability of capillary tube formation and migration. This effect seems to be greatly enhanced by a new class of drugs called ERK inhibitors2.

Tumour samples of mice treated with EGCG clearly show that the cancerous cells have reduced ERK activity while having enhanced p38 and JNK activity. In other words, the pathways that promote growth are down-regulated and the pathways that inhibit growth are up-regulated. The net effect is that the cancer does not grow or spread as quickly. Every molecular marker that was tested indicated that the cancer was less aggressive and more prone to cell death. If you perform a quick Google scholar search, you will see hundreds of well-controlled studies that consistently demonstrate this anti-cancer effect.

When EGCG is combined with curcumin at high doses, it helps to stabilize leukemias and lymphomas. There are many well-documented cases of patients with multiple myeloma who have had long-term disease stabilization by simply taking high doses of EGCG and curcumin. These natural compounds work synergistically to reduce inflammation and promote cell death in cancerous cells. The effectiveness of EGCG in multiple myeloma is undeniable, and this has resulted in a resurgence of research into its use as an adjunctive cancer therapy6.

There are a handful of chemotherapy drugs where the use of EGCG is contraindicated such as bortezomib (Velcade). There is contradictory information about the significance of this interaction, but it is still best to avoid combining EGCG with velcade15. Some doctors focus on this one interaction while ignoring the overwhelming evidence that EGCG often acts synergistically with other forms of chemotherapy. It is difficult to argue against the use of EGCG if you take the time to actually look at the evidence. When EGCG is combined with cisplatin, it not only significantly increases the effectiveness of the drug, it also dramatically reduces the side effect profile7,8,9.

Recently in the media, concerns have been raised about the connection between EGCG and liver toxicity. These liver toxicity reactions that are potentially related to EGCG are exceptionally rare considering how regularly EGCG is consumed in the general population. There have been several documented case studies of liver toxicity that have been connected to use of EGCG. It appears that there may be a genetic predisposition to these rare reactions12. At this point in the time mechanism of action for these reactions is unclear, however, it is in many cases likely due to a immune-allergic mechanism. In other words, it could be that some of these patients were just simply allergic to EGCG.

There is contradictory information regarding the impact of EGCG on liver as several animal studies indicate that it actually has a strong protective effect on the liver and kidneys10. I can tell you from experience that I have literally prescribed EGCG thousands of times and I have never seen even a hint of such reaction. EGCG is a exceptionally safe supplement when used appropriately and patients should not be fearful of using it due to a handful of exceptionally rare cases of liver toxicity.

EGCG is an example of a supplement where the quality makes a significant difference. In order to obtain the desired anti-cancer effect, you must take high doses of quality EGCG. Drinking green tea may be helpful in the context of cancer prevention, but when it comes to cancer treatment, you need much higher doses. Some physicians recommend that patients get EGCG administered by intravenous therapy to get the doses as high as possible. The doses required to enhance chemotherapy and promote cell death in cancerous cells are quite high, but they are obtainable by consuming EGCG orally. It is also important to point out that this treatment is cost effective and generally well tolerated by patients.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative cancer care, providing the best care in integrative oncology. http://www.yaletownnaturopathic.com

Dr. McLeod will be holding two seminars in 2018, Vancouver, British Columbia and Toronto, Ontario. For more information on his seminars please visit the website: http://www.dreamhealer.com/workshop/

References:

1) Ahmad, Nihal, Sanjay Gupta, and Hasan Mukhtar. “Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells.” Archives of biochemistry and biophysics 376.2 (2000): 338-346.

2) Shankar, Sharmila, et al. “EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer.” Frontiers in bioscience: a journal and virtual library 13 (2007): 440-452.

3) Hwang, Jin-Taek, et al. “Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway.” Cancer letters 247.1 (2007): 115-121.

4) Shimizu, Masahito, et al. “EGCG inhibits activation of HER3 and expression of cyclooxygenase-2 in human colon cancer cells.” Journal of experimental therapeutics & oncology 5.1 (2004): 69-78.

5) Shah, Jatin J., Deborah J. Kuhn, and Robert Z. Orlowski. “Bortezomib and EGCG: no green tea for you?.” Blood 113.23 (2009): 5695-5696.

6) Shammas, Masood A., et al. “Specific killing of multiple myeloma cells by (-)-epigallocatechin-3-gallate extracted from green tea: biologic activity and therapeutic implications.” Blood 108.8 (2006): 2804-2810.

7) El-Mowafy, A. M., et al. “Novel chemotherapeutic and renal protective effects for the green tea (EGCG): role of oxidative stress and inflammatory-cytokine signaling.” Phytomedicine 17.14 (2010): 1067-1075.

8) Davenport, Andrew, et al. “Celastrol and an EGCG pro-drug exhibit potent chemosensitizing activity in human leukemia cells.” International journal of molecular medicine 25.3 (2010): 465-470.

9) Sarkar, Fazlul H., and Yiwei Li. “Using chemopreventive agents to enhance the efficacy of cancer therapy.” Cancer Research 66.7 (2006): 3347-3350.

10) Niu, Yucun, et al. “The phytochemical, EGCG, extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats.” Aging Cell 12.6 (2013): 1041-1049.

11) Chen, Ju-Hua, et al. “Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide–derived prooxidants.” The American journal of clinical nutrition 80.3 (2004): 742-751.

12) Church, Rachel J., et al. “Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice.” Food and Chemical Toxicology 76 (2015): 19-26.

What’s the Hype About the Paleo Diet? July 28, 2016

Posted by Dreamhealer in best vancouver naturopath, best vancouver nutritionist, Diet, Healing, Health, Naturopathic Doctor, Naturopathic Medicine.
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Written by: Dr. Kaleigh Coolsaet

The Paleolithic diet, shortened to the ‘Paleo’ Diet, is becoming more popular and more people are starting to adapt it into their healthy lifestyle. Most patients come in asking what exactly is a paleo diet, is it healthy, and is it right for me?

The paleo diet is a nutrient dense way of eating based on eating a variety of quality meats, seafood, vegetables, fruits, eggs, nuts and seeds. It focuses on eating whole foods that have not been processed, while avoiding nutrient poor processed and refined foods.

When eating a paleo diet, and focusing on nutrient rich foods this in turns improves our health by helping improve digestion through healing our digestive tract and feeding the healthy bacteria. It also has other benefits for our bodies as it can improve our immune function, improve our ability to regulate hormones and boost our metabolism.

The foods that are avoided in the paleo diet including grains, legumes, dairy, alcohol, sugar. These foods are pro-inflammatory to our system. These foods tend to be calorie rich, and nutrient poor; what we call “empty calories”. They can also cause irritation to our digestive tract. So by eliminating these foods from our diet, we are able to focus on more nutrient dense, and healing foods to help us improve energy and nourish our bodies.

Foods to Include Foods to Avoid
Vegetables Grains
Fruits Dairy
Lean meats Legumes
Poultry Starches & Sugars
Seafood Processed Foods
Nuts & Seeds Alcohol
Healthy fats Highly refined & processed fats

On a metabolic level the paleo diet helps improve lean muscle mass, reduce excess body fat and maintaining stable blood sugar levels. It provides your body with all the nutrients for maintaining stable energy levelsthroughout the day and can help improve your sleep quality.

In summary, the paleo diet is a nutrient dense and anti-inflammatory diet, which can help improve many conditions including: Allergies, IBS, Diabetes, Skin conditions (ex. Eczema, Psoriasis), Depression, Cancer, Obesity, Infertility and more.

Is the paleo diet right for you? Before starting any dietary changes it is always recommended to speak to your healthcare practitioner to make sure you are eating and maintaining a balanced diet.

Best in Health,

Dr. Kaleigh

Dr. Kaleigh Coolsaet practices at Yaletown Naturopathic Clinic, contact us today to book you appointment by email info@yaletownnaturopathic.com. Get well, stay well.

Naturopathic Medicine Should be a First Resort, Not a Last Resort July 14, 2016

Posted by Dreamhealer in best vancouver naturopath, Cancer, cancer therapy, Cancer Treatment, Healing, integrative cancer care, Naturopathic Doctor, Naturopathic Medicine.
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Written By: Dr. Adam McLeod, ND, BSc (Hons)

With any treatment plan the goal is to always use the least invasive therapy first before considering more aggressive invasive therapy. This makes it more likely that the health concern can be effectively treated without harming the patient. If someone has a mild infection that can be easily treated with a well tolerated low dose oral antibiotic then it makes sense to use this prior to trying high dose intravenous antibiotics that are more likely to cause complications. This rationale is common sense.

When faced with a diagnosis of cancer, patients are often overwhelmed with information and this can scare them into immediately resorting to the most aggressive treatment plan possible and in the process natural therapies are dismissed out of fear. In many cases, only after all conventional options have been exhausted do they seek integrative care. This is not the ideal time to integrate natural therapies into the plan as the bodies immune system is often severely weakened at this point in time. Naturopathic medicine should be integrated into the plan from the first day of diagnosis.

I am not in any way suggesting that patients should be avoiding conventional care. The evidence is clear, patients do better when they have an integrative health care team. This means that conventional and natural therapies are used together in a synergistic manner. After consulting with their oncologist, some patients are left with the impression that there is no evidence to support any therapy beyond what is being recommended. This could not be further from the truth. These therapies have hundreds of peer reviewed studies and depending on where you are in the world they can be the standard of care. In many major cancer centres in the USA, naturopathic doctors are now working in hospitals along side medical oncologists and patients are doing better as a result.

Naturopathic medicine can be very effective at supporting the immune system and reducing side effects during conventional cancer therapies. You can do all the chemotherapy in the world but if you do not have a functioning immune system to clean up the metabolic mess then it will not be a successful plan. This is where naturopathic medicine excels and it should be used from day one. It is not unusual for me to have patients at my office using the strongest and most toxic chemotherapy that medicine has to offer, and they breeze through it with minimal side effects.

It is critical to recognize that you must have professional guidance when developing an integrative treatment plan. Do not take advice from friends or the internet and start taking a supplement because you heard it was good for cancer. Not all cancers are the same and there are legitimate interactions that you must be aware of. Only a naturopathic doctor who works with oncology will be able to help you develop a targeted and effective treatment plan that is indicated for your unique health circumstances. Working with a naturopathic doctor also makes it possible to have true integrative care where multiple health care practitioners are working collaboratively on your case.

You do not have to take these supplements in secret. If you desire an integrative treatment plan then your naturopathic doctor should be making an effort to reach out to your oncologist to inform them about what you are taking. When oncologists are provided with information about what you are taking and why, they are often happy to work collaboratively. Both naturopathic medicine and conventional medicine have a lot that they can offer patients. The ideal treatment plan does not have to be one extreme where the other healthcare practitioners are completely disregarded. The most effective plan is a collaborative integrative plan that is developed based on the best available scientific evidence. Integrating naturopathic medicine with conventional medicine should be every patients first resort, not their last.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

Naturopathic Doctors – Medically Trained, but Naturally Focused. June 23, 2016

Posted by Dreamhealer in best vancouver naturopath, Healing, Naturopathic Doctor, Naturopathic Medicine, Supplements.
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As we celebrate the advances that naturopathic medicine has been making, we also have to acknowledge the recent negativity being directed at our profession from certain groups within the medical world and their media minions. A recent tragic case in Alberta saw a couple being convicted of failing to provide the necessities of life for their young son, who died of bacterial meningitis in 2012. Over the course of this case, it was revealed that they had contacted one of our Alberta naturopathic doctors by phone, who had instructed her staff to tell them to take the child to seek emergency medical care. The next day, someone (who later turned out to be a member of the same family) came into her clinic to purchase an herbal immune support formula, something that would commonly be available over the counter at any number of natural pharmacies across Canada. However, subsequent to this, a group of Alberta medical doctors took it upon themselves to call for an investigation into the actions of the ND – the same ND who didn’t see the child, didn’t provide any medical advice other than to go to the ER, and didn’t provide any treatment.

Similarly, our friends at the Globe and Mail have been very active in displaying their bias against safe, natural medicine, doing their best to misrepresent facts to distort the truth. This brings to mind a CBC Marketplace “investigation” from a few years back, that claimed to answer once and for all, whether homeopathy was an effective health care modality. Luckily, they made it perfectly obvious that they didn’t consult a single person with any knowledge or training in homeopathy, as they designed their “study” in such a way as to render it utterly useless. An analogy I could make – if they took a prescription sleep aid, rubbed it on their forehead, then went to bed with it under their pillow – then came to the “scientific” conclusion that it didn’t work.

But most alarming was this editorial penned by Peter McKnight, a journalist whose training in anything medically related extends to an undergraduate degree in psychology. He attempts to convince his readers that Western medicine long ago threw out the notion of the “healing power of nature”, implying that the only thing standing in the way of the certain annihilation of the human race by disease is an army of white-coated medical doctors armed with their trusty prescription pads. If you find me one doctor who tells you that the human body doesn’t have the ability to heal itself, I’ll show you a doctor who is either ignorant or lying. Everyone (including every parent in the world) knows that the body will heal itself, as long as you remove whatever factor is in the way of that. And in fact – if that vis medicatrix naturae isn’t present, nothing any doctor does will have any effect on actually healing a patient, save for keeping them alive. If your kid scrapes his knee – you clean it well, keep it clean, and keep your child from picking at the obviously fascinating scab that will form – and it will heal. On its own. Extend that to a multitude of illnesses, and you’ll find that once you remove the obstacles to health (poor diet and lifestyle, lack of sleep, nutritional deficits, chronic assault from environmental toxins, stress, etc), for the most part, patients will return to a state of health.

A common complaint about naturopathic medicine is around safety and efficacy. They say that manufacturers of natural supplements aren’t required to demonstrate efficacy to Health Canada before having them approved for sale. But they are required to demonstrate safety. With regards to safety, I’m not aware of a single case of a patient dying as a result of any medical intervention by a licensed naturopathic doctor. Compare that to the statistic that medical error is now the third-leading cause of death in the US. Let he who is without a single dead patient cast the first stone, I say.

Regarding efficacy – let’s break this down a little. For medical doctors accustomed to using pharmaceuticals to force the body back into line, they typically see results on the order of days to a few weeks. If there’s no clear benefit in that time, you can conclude the treatment is ineffective. Applying that same quantifier to natural remedies is like comparing apples to oranges. As stated earlier, naturopathic medicine focuses on encouraging a return to health, through (for the most part) gentle interventions that gradually shift the body’s health on both a physical and energetic level. Most people I see have spent years or even decades gradually getting to their current state of ill health. Any intervention that claims to return them to health in a few days will not work, simply because once the medication is discontinued, the body will revert to the state to which it has become accustomed.

Furthermore, if you equate the efficacy of a treatment to a cure, we must consider how many classes of drugs actually purport to “cure” anything”. One notable exception would be antimicrobials for a bacterial or fungal infection. Go beyond that, and the cure rate drops significantly. Anti-depressants only work as long as people remain on the medication (assuming they work at all, or don’t make the condition worse). Statins artificially lower cholesterol levels, which return to pre-treatment levels upon discontinuation of the drug. Same with medications for high blood pressure, stomach acid levels, sleep and anxiety, the list goes on. Until the obstacles to health are removed, health will not be achieved.

In this, the stark difference between naturopathic doctors and medical doctors – the question “why?”. Why are these symptoms occurring? Naturopathic doctors aim to find and treat the cause of illness, rather than simply playing whack-a-mole with symptoms by prescribing one medication after another, often to simply treat the side effects created by the original drug.

So in conclusion, happy Naturopathic Medicine Week, to the tens of thousands of happy and healthy patients across Canada who attribute their good health to their naturopathic care, and to the growing group of allies within the conventional medical community – modern doctors and nurses who recognize the benefit to patients of collaborative and complementary medicine. To the rest of you – the dinosaurs who continue their desperate campaign to convince the public that you’ve got all the answers, that pharmaceuticals are the only way to go, and that under no circumstances, should they ever ask you “why” – it’s not too late to join the right side of history. The future of medicine will be found in the middle ground, currently populated with medically-focused naturopathic doctors and medical doctors practicing what they’ve termed “functional medicine” – where through a mixture of modern innovation and traditional healing we create a paradigm of health – instead of treating disease.

Naturopathic doctors – Medically Trained, but Naturally Focused.

In Health,

Dr. Reuben Dinsmore, ND

http://www.theglobeandmail.com/opinion/message-to-naturopaths-magic-isnt-medicine/article29929971/

IBS – But What CAN I Eat? May 12, 2016

Posted by Dreamhealer in best vancouver naturopath, best vancouver nutritionist, Diet, Healing, Naturopathic Doctor, Naturopathic Medicine, naturpathic medicine, stress.
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Written by: Breanne Dunlop, RHN

Suffering from abdominal pain, cramps, bloating, and gas? You’ve likely been told it could be IBS. Irritable bowel syndrome is the diagnosis often given to people who suffer from uncomfortable symptoms regarding the gut and bowels, and is distinct from Irritable Bowel Disease as the cause of irritation is unknown. IBS as you can imagine is extremely uncomfortable for those who suffer from it. Symptoms can be chronic or sporadic but are typically triggered by certain foods or during periods of stress. Some individuals are more prone to constipation while others may experience diarrhea. Whether you are chronically dealing with gut pain or have anxiety about being out in public during a flare up, IBS can be very crippling for many of its sufferers.

Since the cause of irritation is unknown and is likely different for everyone, the remedies to help provide some relief will be different too. The only sure way to know what may help you is through trial and error. Food is meant to be therapeutic and nourishing but for IBS sufferers it can be a nightmare trying to figure out what you can tolerate and what brings you agony. Right now there are three diets recognized to help with IBS: SCD, FODMAP or GAPS.

Specific Carbohydrate Diet (SCD) is a whole foods diet that avoids processed foods, sugars, starches and grains. The belief here is that complex carbohydrates are slow to digest and the pathogens bad little critters in our gut feed off of them. Only monosaccharides (simple sugars) are permitted on this diet as they are easier on the digestive tract. When food is properly digested and absorbed, there is nothing left in the gut for the bad little critters to feed on.

FODMAPs stands for Fermentable Oligosaccharides Disaccharides Monosaccharides and Polyols and aims to starve the bad bacteria by limiting foods that are poorly absorbed in the small intestine. FODMAPS has been further researched since SCD was introduced and therefore limits more foods (including monosaccharides) that are now known to be troublesome for an irritated gut. Foods are rated as low, medium or high FODMAP and the goal is to limit as much as possible high FODMAP foods because when eaten in excess these foods feed pathogens in the gut.

Gut And Psychology Syndrome (GAPS) is more restrictive than the previously mentioned diets, especially in the introductory phase. GAPS has more of a therapeutic approach to heal the gut versus just eliminating foods that are causing damage. The introductory phase, which lasts three to six weeks, consists entirely of homemade meat stock and vegetables with added probiotic rich foods such as sauerkraut – so hopefully you love soup!

Tired of suffering with your IBS? A holistic nutritionist can provide guidance on how to successfully eliminate trigger foods and incorporate foods and supplements that will help repair and nourish your gut. No more gut pain = a healthier and happier you. Book an appointment with Breanne today for assistance on how to implement one of the above diets into your lifestyle.

Weight Loss and Cancer April 28, 2016

Posted by Dreamhealer in Cancer, cancer therapy, Cancer Treatment, Healing, immunity, integrative cancer care, Naturopathic Doctor, Naturopathic Medicine, Naturopathy, nutrition.
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Written By: Dr. Adam McLeod, ND, BSc (Hons)

Everyone has seen a cancer patient who has lost a significant amount of weight as the disease progressed. It is a scary experience to see someone that you love waste away as the cancer deprives their body of the nutrients that they so desperately need. In the chaos of going from one appointment to the next, patients often do not realize how malnourished they have become.

The significant wasting that late stage cancer patients experience is known as cachexia. To understand why this happens it is helpful to look at the molecular pathways relevant to cachexia. The exact mechanism is not well defined but inflammatory cytokines are thought to play a major role. Cancer is a condition that creates significant systemic inflammation and this dramatically increases the concentration of inflammatory cytokines through out the body. The most prominent inflammatory cytokines during cachexia are often TNF-a and IL6 5.

The good news is that there are a number of natural tools which can help to significantly reduce these inflammatory cytokines. Of course there are cases where the disease has progressed to the point where it is not possible to reverse the effects of cachexia. However, in my clinical practice I have seen many patients reverse the effects of cachexia rather quickly when the correct natural supports are used. When we take the time to look at how these natural supports work it is immediately obvious why they can be so effective.

Omega-3’s are potent natural anti-inflammatories and specifically they reduce TNF-a and IL6 levels in the body1,2,3. In order to have the desired therapeutic effect from supplementation with omega-3’s it is critical that the proper dose is used. Many supplements (especially pill forms) containing omega-3’s do not have the appropriate dose of eicosapentaenoic acid(EPA) and this will not have any impact on an extreme case such as cachexia. When the appropriate dosing is used sometimes patients can see significant improvements in cachexia from supplementing with omega-3’s 4.

Cancer loves L-glutamine and it uses it in high amounts to support its metabolic needs. Some patients upon hearing this falsely assume that removing glutamine from the diet would then starve cancer cells. This is the wrong approach to take. Cancer cells will get glutamine whether you have it in your diet or not. If it is not in your diet then the cancer cells will cause the muscles to break down so that the glutamine can be extracted from the muscles. This will rapidly worsen the cachexia. The simplistic view that if cancer uses a substance then it should be avoided is not always correct in these complex clinical cases. When patients are supported with adequate amounts of glutamine this can help to slow down muscle breakdown and give healthy cells the glutamine that they also need to function6. The glutamine is also necessary for your immune system to function properly and this need far outweighs any concerns of “feeding” cancer cells glutamine in cases of cachexia.

In my experience the combination of L-glutamine and omega-3’s can help to heal the gut and this allows cancer patients to absorb nutrients more effectively from their food. A major challenge for advanced cancer patients is that even if they eat enough food, they struggle to adequately absorb nutrients from their food. By supporting gut health with adequate amounts of these simple remedies, this can help to enhance the absorption of nutrients at a time when patients are extremely malnourished.

There are many other natural therapies which can also be applied in cachexia to help improve the patients quality of life. For example, cannabinoids can be used to help stimulate appetite while reducing the sensation of nausea that many of these patients have. In other cases, the use of a Myers IV is indicated to bypass any concerns with absorption and get nutrients directly into the blood. Patients generally feel better when the inflammation is reduced following the application of these various naturopathic supports. It is critical that patients have professional guidance from a qualified naturopathic physician when utilizing these supports. Cachexia is a unique metabolic circumstance that requires the appropriate doses if you expect to see any benefit.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References:

1) Kang, Jing X., and Karsten H. Weylandt. “Modulation of inflammatory cytokines by omega-3 fatty acids.” Lipids in Health and Disease. Springer Netherlands, 2008. 133-143.

2) De Caterina, Raffaele, et al. “The omega-3 fatty acid docosahexaenoate reduces cytokine-induced expression of proatherogenic and proinflammatory proteins in human endothelial cells.” Arteriosclerosis, Thrombosis, and Vascular Biology 14.11 (1994): 1829-1836.

3) Nelson, Tracy L., and Matthew S. Hickey. “Acute changes in dietary omega-3 fatty acid intake lowers soluble interleukin-6 receptor in healthy adult normal weight and overweight males.” Cytokine 26.5 (2004): 195-201.

4) Radbruch, L., F. Elsner, and P. Trottenberg. “Clinical practice guidelines on cancer cachexia in advanced cancer patients. European Palliative Care Research Collaborative.” (2011).

5) Yeh, Shing-Shing, Kimathi Blackwood, and Michael W. Schuster. “The cytokine basis of cachexia and its treatment: are they ready for prime time?.”Journal of the American Medical Directors Association 9.4 (2008): 219-236.

6) May, Patricia Eubanks, et al. “Reversal of cancer-related wasting using oral supplementation with a combination of β-hydroxy-β-methylbutyrate, arginine, and glutamine.” The American journal of surgery 183.4 (2002): 471-479.

Turning up the Heat on Colorectal Cancer March 17, 2016

Posted by Dreamhealer in Alternative medicine, best vancouver naturopath, cancer therapy, Cancer Treatment, Healing, Health, integrative cancer care, Naturopathic Doctor, Naturopathic Medicine.
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Written By: Dr. Adam McLeod, ND, BSc (Hons)

Loco-regional hyperthermia is an advanced adjunctive cancer therapy which involves heating the tumour immediately after chemotherapy or radiation. Hyperthermia is characterized as the fourth pillar in treating cancer, including surgery, chemotherapy and radiation. This therapy is commonly used in hospitals and clinics across Europe and Asia but it is oddly not used regularly in North America. There are only a few advanced devices which actually have the capacity to significantly heat a tumour located deep within the body1,2. Recently there has been exciting research on a device called Celsius TCS and its use in colorectal cancer.

A recent clinical study in Greece investigated hyperthermia in patients with metastatic colorectal cancer when used in combination with chemotherapy1. In this clinical trial 32 patients diagnosed with colorectal cancer were divided into a control group who just received chemotherapy and the treatment group who received hyperthermia immediately following their chemotherapy infusion. When compared to the control group, the hyperthermia group showed a shrinkage of metastatic spots derived from colon cancer. This is in contrast to the control group which on average showed an increase of size during this time interval. The conclusion of the study was “the beneficial effects of hyperthermia are undeniable. The consolidation of the application of hyperthermia cancer treatment, is now a matter of time.”

I have personally observed the positive benefits of loco-regional hyperthermia many times in my practice with colorectal cancer. In some of these cases the cancer was progressing everywhere except for the specific masses that were being targeted by the hyperthermia. Upon shifting the treatment focus to a different metastasis, these new masses then started to also respond to the therapy as well. The heat that is applied to the tumour adds additional stress to the tumour cells when they are being treated with chemotherapy or radiation.

There are several naturopathic therapies which can be used to potentially help enhance the effectiveness of hyperthermia. Quercetin is a bioflavonoid that is safe to use in conjunction with some chemotherapies. This commonly used remedy is not safe with all chemotherapies and you must have professional guidance before using it. Quercetin has been shown to be a potent inhibitor of heat shock proteins. In other words, it inhibits the proteins that cancer cells use to resist the effects of the heat and thus makes colon cancer cells more vulnerable to hyperthermia3. There is also research to suggest that the diabetes medication metformin may be helpful to enhance the effects of hyperthermia by killing cancer stem cells4. These are just a few of many natural therapies which as starting to show promise as useful adjuncts to hyperthermia.

It is important to point out that hyperthermia is very different from an infrared sauna or the application of a heat pack. A loco-regional hyperthermia device is an advanced medical device that significantly heats the tissues surrounding a tumour2. You will not heat any tumour effectively without these advanced devices, especially if it is a deeper tumour. These are state of the art devices where the patient must be medically monitored during the procedure.

When looking at the evidence there is a clear and consistent trend. Localized hyperthermia has significant potential as an adjunctive cancer therapy. The application of heat using these advanced medical devices increases the effectiveness or chemotherapy and radiation. Hyperthermia reduces the risk of the cancer developing resistance to chemotherapy or radiation5,6,7. At the end of the day the goal is to use every tool at our disposal to increase the effectiveness of conventional therapies and destroy the cancerous cells. Hyperthermia is a potent adjunctive therapy that can help to accomplish that goal.

References:

1) Mandraveli, E., et al. “The action of hyperthermia in metastatic colorectal cancer in combination with chemotherapy.” Progress in Health Sciences 5.1 (2015): 69.

2) Noh, Jae Myoung, et al. “In vivo verification of regional hyperthermia in the liver.” Radiation oncology journal 32.4 (2014): 256-261.

3) Koishi, Mototsugu, et al. “Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line.” Japanese journal of cancer research83.11 (1992): 1216-1222.

4) Lee, Hyemi, et al. “Response of breast cancer cells and cancer stem cells to metformin and hyperthermia alone or combined.” PLoS One9.2 (2014): e87979.

5) Group, International Collaborative Hyperthermia, et al. “Radiotherapy with or without hyperthermia in the treatment of superficial localized breast cancer: Results from five randomized controlled trials.” International Journal of Radiation Oncology* Biology* Physics35.4 (1996): 731-744.

6) Uckun, Fatih M., et al. “Radiation and heat sensitivity of human T-lineage acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML) clones displaying multiple drug resistance (MDR).”International Journal of Radiation Oncology* Biology* Physics23.1 (1992): 115-125.

7) Souslova, Tatiana, and Diana A. Averill-Bates. “Multidrug-resistant hela cells overexpressing MRP1 exhibit sensitivity to cell killing by hyperthermia: interactions with etoposide.”International Journal of Radiation Oncology* Biology* Physics 60.5 (2004): 1538-1551.

The Real Truth About Cancer February 22, 2016

Posted by Dreamhealer in best vancouver naturopath, Cancer, cancer therapy, Healing, Naturopathic Doctor, Naturopathic Medicine, oncology.
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6 comments

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Written By: Dr. Adam McLeod, ND, BSc (Hons)

Recently there have been a surge in patients seeking alternative cures for cancer after watching the popular series “The Truth About Cancer”. This series does an excellent job of raising awareness about various natural therapies but it does patients a great disservice by discouraging patients from using conventional therapies. This documentary has given patients a biased view point and as a consequence they feel very polarized in their opinion against conventional care. The problem is that the best treatment plan involves integrating these two worlds together. Both conventional therapies and natural therapies have a lot that they can offer patients but they must be used together in a synergistic way for optimal results.

Patients have the right to choose what ever treatment plan they want. As a Naturopathic physician I have always respected my patients choices, even if I disagree with that choice. It is not my job to force the patient to choose a treatment plan, it is my job to give them the information and then they choose the treatment plan that feels right to them. When developing a treatment plan the key word is “integrative” not “alternative”. This means using natural tools safely and effectively in conjunction with conventional therapies. An integrative approach is what any licensed naturopathic doctor would be recommending and unfortunately this documentary confuses the public by giving them the impression that naturopathic doctors are against conventional cancer treatments. By presenting such a polarized view it often discourages patients from seeking true integrative care that could really benefit them.

Make no mistake about it, I am a big believer in the healing power of nature but this series greatly exaggerates the effectiveness of many natural therapies. Of course there are home runs with simple natural therapies. I have personally witnessed on many occasions where patients have dramatic responses to the simplest natural therapies. Although these responses are amazing and they require further investigation, it does not mean that everyone should abandon all conventional therapies in favour of an alternative approach. What the documentary fails to document is the many people who chose to pursue only alternative therapies and had poor responses. Cancer is unforgiving of delays and poor choices. It is true that chemotherapy, radiation and surgery have side effects but cancer has side effects too.

Many of the natural therapies that this documentary chooses to highlight are not commonly recommended by experts who work in the integrative oncology field. Things like baking soda and apricot seeds are not mainstream natural cancer therapies and have virtually no evidence of being effective. There are countless natural therapies which are more effective than this and which are well supported by scientific evidence. Not all cancers are the same and you must have professional guidance when developing a plan. Many natural therapies are completely contraindicated in certain cancers and just because it is natural does not mean that it is universally safe.

Of course there are times where the use of chemotherapy is questionable. In some circumstances the cancer is unlikely to respond to the drug and intensive therapies are being recommended to only slightly extend life expectancy. In these cases the lowered quality of life must be weighed against the increased life expectancy. There are certainly cases like this where the medical oncologists are only recommending such therapies because there are no other options. It is not unreasonable for patients to resist conventional care in some of these extreme circumstances.

The key thing to recognize is that this does not apply to all cases of cancer. Conventional cancer treatments save lives when used in a timely fashion. The study cited in the series that states the ineffectiveness of chemotherapy is not presenting this information properly. This study is questioning the use of chemotherapy in the context of 5 year survival rate. By the time many of these cancers in the study were diagnosed, the disease had already greatly progressed and it is unlikely that anyone would live for 5 years, regardless of what therapy they choose.

When you take the time to dig deeper into the study it is clear that in many of these cancers the patients are living significantly longer but many of them are not living up to the 5 year mark. In this particular study someone could live for several years with a great quality of life but if they died at 4 years and 11 months then the chemotherapy would be considered ineffective. Obviously if a patient is able to live longer with a good quality of life, this is a success even if they don’t live for 5 years. The public is often left with this false impression that all chemotherapy leaves patients with a crippled quality of life. Certainly some chemotherapies significantly decrease quality of life but not all chemotherapy is the same. Particularly when patients are well supported they have significantly less side effects and can live with a great quality of life. It is not unusual for me to have a patient come to my office who has minimal side effects even when doing an intense round of chemotherapy because they are well supported naturally during this process.

You will never have all studies agree as this is how science works. We cannot base our clinical decisions on one study, we must base it on the totality of the evidence. A quick literature search will find thousands of peer reviewed studies demonstrating the effectiveness of chemotherapy for a wide range of cancers. I have had many patients in the past refuse conventional care against my advice and fly to exotic clinics around the world to receive alternative therapies. During these unnecessary delays the cancer spread to the point that it was no longer curable. In some of these cases I was confident that the patient could have been easily cured had they not hesitated.

Natural therapies can be used to help support patients through conventional treatments. They can help to significantly reduce side effects and support the immune system. When patients have this support not only do they respond better to therapy, they are more likely to embrace both therapies as their answer to this terrible disease. Often those who are the most polarized in their opinions against an integrative approach are people with little to no experience dealing with cancer. These two worlds can coexist and it is a beautiful thing when there is true collaboration.

The bottom line is that a balanced approach is best. The extreme view that no natural therapies work is simply incorrect. Just as the extreme view that only natural therapies should be used is inaccurate. The best treatment plan is an integrative approach which bridges these two worlds. Many patients get scared away from conventional therapies because their oncologist presents the treatments with such a polarized point of view. When you are trained as a hammer, everything looks like a nail. This becomes obvious to many patients after meeting with their oncologist who has a limited set of tools to offer. There are a vast range of natural therapies that can be used to help your body fight cancer but they have to be used in the proper clinical context. A Naturopathic doctor who works with oncology can help to give you a more balanced view and develop a treatment plan that utilizes the best of both worlds.

Dr. McLeod is currently accepting new patients at Yaletown Naturopathic Clinic, please call 604-235-8068 to book an appointment or for more information about integrative oncology treatments. Yaletown Naturopathic is also one of only a few clinics in all of North America who offers Loco Regional Hyperthermia to patients who qualify for this treatment.

Get well. Stay well. 

Detoxification and Cancer February 15, 2016

Posted by Dreamhealer in best vancouver naturopath, Cancer, Healing, integrative cancer care, Naturopathic Doctor, Naturopathic Medicine.
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3 comments

cancer-detox-diet-juicing-710x400

Written By: Dr. Adam McLeod, ND, BSc (Hons)

On a regular basis I have cancer patients come to my clinic who when diagnosed immediately started a self prescribed detox protocol to rid their body of the toxins from cancer. Intuitively it makes sense to remove toxins from a body fighting cancer. The cancer is very stressful on the body and as a consequence there is cellular debris and toxins that your body must eliminate. There are also many people who believe these toxins are the root cause of the cancer in the first place. Although this make sense on an intuitive level, in the complicated clinical context of cancer this is usually not a good treatment plan to pursue.

Cancer and the conventional therapies used to treat cancer are toxic to the body, but aggressively trying to remove these toxins is not helpful during conventional treatment. One major safety concern that many self prescribed plans neglect to consider is that these detox plans can alter how your body metabolizes the drug. When a dose of chemotherapy is given to a patient, the dose is calculated based on how quickly the body breaks down and eliminates the drug. If your body breaks down the drug faster then it will be eliminated before it has the chance to have its therapeutic effect. Just because a drug is considered “toxic” doesn’t mean that we have to get rid of it as soon as possible. In fact, often we want that drug to remain present for a specific amount of time so that it can have an optimal therapeutic effect.

The whole purpose of any detox plan is to mobilize toxins and eliminate them from the body. This process is inherently stressful on the body and can actually increase inflammation through out the body. This is why patients will often experience joint pain upon initiating a detox protocol. When the body is already in such a stressed and inflamed state from cancer, it is not wise to add any additional stress to the system. After chemotherapy or radiation is complete, then there could be an argument for a detox but even then it must be done at the right time, with the proper guidance.

The challenge when developing an effective integrative cancer treatment plan is that there are so many different therapies that show promise. There is a lot of misinformation on the internet and not all cancers are the same! Just because you read that a therapy was helpful for someone fighting cancer, this does not mean that it would be relevant to a different form of cancer. We have to prioritize the treatment plan and keep it targeted on the common goal of supporting the immune system while controlling inflammation. There are many natural ways to do this but in order for them to be used safely it has to be used in the right clinical context.

The bottom line is that if you are trying to support your body through any cancer therapy, you need professional guidance. Do not develop a plan on your own as not all natural therapies are safe or indicated in specific circumstances. A significant portion of my job as a Naturopathic Physician who focuses on integrative oncology is just making sure patients are not taking supplements that are dangerous. On an almost daily basis I see patients who self prescribed a supplement that is contraindicated or ineffective for their cancer and they never told their oncologist because they were afraid of how they would react. After a Naturopathic Physician develops a safe and effective plan they can then communicate with the oncologist so that everyone is on the same page. This creates a better collaborative healing environment for the patient and allows for the development of a more effective treatment plan.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

Fresh Start…? February 11, 2016

Posted by Dreamhealer in best vancouver naturopath, Healing, Naturopathic Doctor, Naturopathic Medicine.
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1 comment so far

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Somehow January is over. Have you gotten going on your 2016 new years’ resolutions? Are you feeling successful? Is the momentum petering out?

It’s easy to feel inspired at least for a little while by all the hype around a resolution at this time of year. It’s also easy to feel bombarded by pressure to be successful at this goal you set. Here are a few ideas to get you through the pressure and maybe even help you drop the resolution altogether!

  1. Intention is more powerful than resolution. 
    A resolution tends to carry power in the pressure department. Some people do well at them for a time because they feel the world is watching, holding them accountable and that’s exactly what they need. This may not resonate with everyone.

An intention comes from inside and acts more like scaffolding, helping to raise the structure of the things you want to bring into your life. It’s longer acting and gentle enough that you can revisit them easily if you find you have strayed.

  1. Winter is time for hibernation.
    I believe that one of the reasons resolutions set some up for failure is because some resolutions involve great action. Typical ones would be to exercise regularly, run more, eat less, eat better, etc.

If you are someone who needs a bit more meaning or connection to your goals, you’ll be interested to know that in the Shamanic world, winter is a time of stillness. It’s a time to go inside, hibernate, let go and clear space, letting the old stuff die and be removed to make room for the upcoming spring and return to life.

I find it’s the best time to take time and listen. To go with the natural tendency towards stillness. To allow in what is meant to come and to form intentions for the rest of the year from this place of quiet connection.

  1. Get clear and ask for help.
    What I love most about the idea of a fresh start with a new year is that it’s an opportunity to get really clear in what you want to call in this year. And sometimes that means simply asking and then letting go of the question.

If you have a resolution you already feel good about then re-examining what the intention behind it might help bolster you forward or tweak it to fit the big picture. Is losing that extra 10 pounds really about the exercise and food? Or can you also bring in the intention to work a bit less and give yourself more stress-free time for joy and sleep, removing a big obstacle to losing that weight.

If you’re at a loss, might I suggest making time for more TLC? It’s my favourite prescription, be it a massage, acupuncture, tea and a good book or a walk in the woods. TLC can also take on the form of asking for help more, giving yourself a break and recognizing that you don’t have to do it all.

Whatever you resolve to do or intend to bring in, remember to check in and to take yourself into account along the way.

A gentle and strong fresh start to you!

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