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Mistletoe the Parasite October 1, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Health.
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Mistletoe is a parasitic plant that directly derives almost all of its nutrition from other flowering plants. By parasitizing other plants, they have a competitive advantage over many other forms of life because they do not have to compete in soil for their water and nutrient needs. This description of mistletoe sounds surprisingly similar to how cancer operates. When you look at mistletoe growing on a tree it looks very much like a tumour. Cancer gets all of its nutrition from other cells within the human body and it has a competitive advantage because it does not abide by the same rules as other cells in the body.

It turns out the mistletoe can be used to effectively treat cancer, even in advanced cases1,2,3. In North America this is often considered a “fringe treatment” yet if you go to Germany this is a mainstream therapy that is well established by the scientific community. The use of mistletoe dramatically reduces the side effects associated with chemotherapy and radiation. The effects are so dramatic that some countries have already made this the standard of care for cancer treatment. The use of mistletoe as the new standard of care was of huge financial benefit to these countries because of the significant decrease in complications from chemotherapy and radiation.

Although there are several different ways to administer mistletoe, the most common is regular subcutaneous injections. This involves the use of small insulin needles and injecting the mistletoe just under the skin. After injecting the mistletoe lectins the immune system immediately begins to attack the injected fluid resulting in a small red rash around the injection site. This immune activation is an excellent outcome in the context of cancer. By activating the immune system at the site of injection it consequently activates the immune system in the entire body.

Mistletoe has been shown to stimulate increases in the number and the activity of several types of white blood cells4. Immune-system-enhancing cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor -alpha, are released by white blood cells after exposure to mistletoeextracts5,6. Other evidence suggests that mistletoe exerts its cytotoxic effects by interfering with protein synthesis in target cells and by inducing apoptosis7.

Just like any cancer therapy it is essential that it is used in the right context. When this therapy is used there will initially be a swelling of the tumour, this is a consequence of the immune activation. If there are any detectable masses contained within the skull, then clearly swelling is not desirable. Mistletoe therapy is contraindicated in patients that have any detectable mass in the brain. It also must be used with caution on patients that are are cachexic and malnourished. The sudden release of cytokines associated with immune activation can worsen the malnourished state.

Mistletoe therapy only costs approximately $250 dollars per month and it can be used in conjunction with other medical therapies. I regularly use mistletoe with my patients at the clinic and it is an effective cancer therapy when used appropriately. On a regular basis I see patients improve when they use this therapy as part of a comprehensive integrative cancer therapy. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References:

1. Mistletoe. In: Murray MT: The Healing Power of Herbs. Roseville, Calif: Prima Publishing, 1995, pp 253-9.

2. Samtleben R, Hajto T, Hostanska K, et al.: Mistletoe lectins as immunostimulants (chemistry, pharmacology and clinic). In: Wagner H, ed.: Immunomodulatory Agents from Plants. Basel, Switzerland: Birkhauser Verlag, 1999, pp 223-41.

3. Hajto T, Lanzrein C: Natural killer and antibody-dependent cell-mediated cytotoxicity activities and large granular lymphocyte frequencies in Viscum album-treated breast cancer patients. Oncology 43 (2): 93-7, 1986.

4. Büssing A, Regnery A, Schweizer K: Effects of Viscum album L. on cyclophosphamide-treated peripheral blood mononuclear cells in vitro: sister chromatid exchanges and activation/proliferation marker expression. Cancer Lett 94 (2): 199-205, 1995.

5. Hajto T: Immunomodulatory effects of iscador: a Viscum album preparation. Oncology 43 (Suppl 1): 51-65, 1986.

6. Hajto T, Hostanska K, Frei K, et al.: Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 50 (11): 3322-6, 1990.

7. Mengs U, Schwarz T, Bulitta M, et al.: Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice. Anticancer Res 20 (5B): 3565-8, 2000 Sep- Oct.

My Trip to Peru August 4, 2014

Posted by Dreamhealer in Healing, Naturopathic Medicine, Spirituality.
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Written By: Dr. Adam McLeod, ND, BSc

This summer I had the opportunity to travel to Peru with my father and it was an incredible experience. After a long plane trip from Vancouver, we finally started our trek from Cusco, which is full of Incan history. I was warned before going to Peru that the altitude (11000ft) can make it very difficult to function and that you would need a day to adapt. I did not take these warnings seriously but it became apparent very quickly that the altitude was affecting us both. After our bodies adapted to the thinner air, we then proceeded to a small town called Ollantaytambo, located in the Sacred Valley.

The setting in this sacred valley was very unique. There were Incan ruins scattered all over the valley and it is clear that this was a thriving community at the height of the Incan empire. Some of the ruins were absolutely incredible feats of engineering. I spent hours looking at some of these structures just contemplating how it was even possible to build this. Many of the cuts were made to perfection and the junctions were such a perfect fit that it is not possible to even fit a piece of paper between them.

Amazing rocks in Ollantaytambo

Amazing rocks in Ollantaytambo. They fit perfect even after being exposed to centuries of earthquakes and weather.

Perhaps the most fascinating engineering feat that I saw on this trip was a block of granite that was perfectly cut out of the mountain at a location called the Temple of the Condor. It is easy to visualize how they cut the sides but it boggles the mind when trying to figure out how they cut behind this solid rock. This one particular site is not seen by many tourists in the area. To me, this small corner in Ollantaytambo had more spiritual significance than any other site that I visited in Peru.

Incredible feat of engineering at Temple of the Condor in Ollantaytambo

Incredible feat of engineering at Temple of the Condor in Ollantaytambo

After visiting Ollantaytambo we then decided to visit Machu Picchu. The town at the base of the mountain is called Aguas Calientes and you can only reach it by train. We woke up at 4:30AM to get in line for the buses to Machu Picchu and there were already hundreds of people in front of us. Although Machu Picchu is an incredible ancient city at a beautiful location, it did not hold much spiritual significance to me. I believe that this was due to the fact that there were so many other people there. While on the mountain I made an Alpaca friend who was happy to take a picture with me.

Adam McLeod and his father hanging out with an Alpaca on Machu Picchu

Adam McLeod and his father hanging out with an Alpaca on Machu Picchu

Overall this trip was a very spiritual experience where on many occasions I could feel the emotions from these historical sites. This region has a brutal history as the Spanish came through and destroyed the Incan culture. You can feel the charged emotions from some of these ruins where atrocities occurred. This trip gave me a deep respect for the Incan culture. The ruins that remain despite centuries of wars and earthquakes are a reminder as to how advanced this culture really was.

For more pictures from my trip check out my Flickr account: https://www.flickr.com/photos/dreamhealer/

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

Dreamhealer Clinic is now open! April 26, 2014

Posted by Dreamhealer in Healing.
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 dreamhealer clinic

I am very excited to announce the opening of my new clinic in Vancouver, BC. For the last 10 years I have been studying at university about how the body works on a molecular and physiological level. Finally I have the opportunity to integrate all the amazing tools that Naturopathic medicine has to offer with energy medicine.

Energy medicine blends together very well with Naturopathic medicine to optimize the patients healing. At the clinic I often combine energy medicine with acupuncture. The acupuncture helps to stimulate the meridians and when combined with energy medicine this can rapidly restore the flow of energy in the body.

To read more about the clinic, visit the website: http://www.yaletownnaturopathic.com

If you would like to book an appointment, please send an email to appointments@yaletownnaturopathic.com.

If you want updates on the clinic make sure you follow us on twitter and like us on facebook!

Dr. Adam McLeod, BSc, ND

Bacteria help kids stay healthy! March 30, 2014

Posted by Dreamhealer in Allergies, Alternative medicine, Antibiotics, Colds, Diet, Dreamhealer, Experiments, Healing, Health, Integrative Medicine, naturopathic, Naturopathic Medicine, Naturopathy, Research, Skeptics.
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By: Drs. Kay Judge and Maxine Barish-Wreden

Breaking news: Bacteria help kids stay healthy! In a study published this month in the Journal of Pediatrics, scientist found that daily probiotics help toddlers avoid certain infections. Researchers enrolled 300 children, ages 6 months to 36 months, in day care centers in a double-blinded study. Half of the children received placebos and half received probiotics.

For the children who received probiotics, it was found that there was a reduction in frequency and duration of diarrhea episodes. And surprisingly, there was also a reduction in respiratory tract infections in the children who took probiotics.

The children in the study received the probiotic Lactobaccillus reuteri daily for three months. In addition to the already-mentioned health benefits, the study found a reduction in the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work.

Other studies on probiotics have found that probiotics may help in reducing acute diarrhea, antibiotic-associated diarrhea, atopic eczema, tooth decay, C. diff. bacteria colitis, irritable bowel syndrome and inflammatory bowel disease, including pouchitis.

So what is this miracle drug? Probiotics are live microorganisms numbering over 100 trillion, including over 500 bacterial species, which normally reside in the human intestinal tract. These microorganisms help in digestion, provide the body with nutrients, help the immune system and help keep harmful microorganisms in check.

Common probiotics are Lactobacillus bulgaris, Streptococcus thermophiles, Lactobacillus acidophilus and casei, and Bifidobacteria. One can maintain a healthy balance of these “good bacteria” in the body by taking products which contain live and active cultures of these bacteria. These can include the pill and liquid probiotic supplements, as well as foods such as yogurt, and fermented foods such as brewer’s yeast, miso, sauerkraut or micro algae.

If you need additional nondairy yogurt options, yogurts made from rice, soy and coconut milk are available on the market. Some of these can contain added probiotics that provide the same benefits as regular yogurt. To ensure that you are getting the benefit of the probiotics in the foods that you are eating, pick those that state “live and active cultures” on the label. Also look for supplements that are not close to their expiration date, as the live bacteria dwindle over time.

Retrieved from: http://www.ledger-enquirer.com/2014/03/28/3027893/integrative-medicine-probiotics.html

For more information about alternative medicine check out http://www.dreamhealer.com

Grandma’s Experiences Leave a Mark on Your Genes March 2, 2014

Posted by Dreamhealer in Dreamhealer, Experiments, Genetics, Healing, Naturopathic Medicine, Research, Workshops.
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By: Dan Hurley

Your ancestors’ lousy childhoods or excellent adventures might change your personality, bequeathing anxiety or resilience by altering the epigenetic expressions of genes in the brain.

Darwin and Freud walk into a bar. Two alcoholic mice — a mother and her son — sit on two bar stools, lapping gin from two thimbles.

The mother mouse looks up and says, “Hey, geniuses, tell me how my son got into this sorry state.”

“Bad inheritance,” says Darwin.

“Bad mothering,” says Freud.

For over a hundred years, those two views — nature or nurture, biology or psychology — offered opposing explanations for how behaviors develop and persist, not only within a single individual but across generations.

And then, in 1992, two young scientists following in Freud’s and Darwin’s footsteps actually did walk into a bar. And by the time they walked out, a few beers later, they had begun to forge a revolutionary new synthesis of how life experiences could directly affect your genes — and not only your own life experiences, but those of your mother’s, grandmother’s and beyond.

The bar was in Madrid, where the Cajal Institute, Spain’s oldest academic center for the study of neurobiology, was holding an international meeting. Moshe Szyf, a molecular biologist and geneticist at McGill University in Montreal, had never studied psychology or neurology, but he had been talked into attending by a colleague who thought his work might have some application. Likewise, Michael Meaney, a McGill neurobiologist, had been talked into attending by the same colleague, who thought Meaney’s research into animal models of maternal neglect might benefit from Szyf’s perspective.

“I can still visualize the place — it was a corner bar that specialized in pizza,” Meaney says. “Moshe, being kosher, was interested in kosher calories. Beer is kosher. Moshe can drink beer anywhere. And I’m Irish. So it was perfect.”

The two engaged in animated conversation about a hot new line of research in genetics. Since the 1970s, researchers had known that the tightly wound spools of DNA inside each cell’s nucleus require something extra to tell them exactly which genes to transcribe, whether for a heart cell, a liver cell or a brain cell.

One such extra element is the methyl group, a common structural component of organic molecules. The methyl group works like a placeholder in a cookbook, attaching to the DNA within each cell to select only those recipes — er, genes — necessary for that particular cell’s proteins. Because methyl groups are attached to the genes, residing beside but separate from the double-helix DNA code, the field was dubbed epigenetics, from the prefix epi (Greek for over, outer, above).

Originally these epigenetic changes were believed to occur only during fetal development. But pioneering studies showed that molecular bric-a-brac could be added to DNA in adulthood, setting off a cascade of cellular changes resulting in cancer. Sometimes methyl groups attached to DNA thanks to changes in diet; other times, exposure to certain chemicals appeared to be the cause. Szyf showed that correcting epigenetic changes with drugs could cure certain cancers in animals.

Geneticists were especially surprised to find that epigenetic change could be passed down from parent to child, one generation after the next. A study from Randy Jirtle of Duke University showed that when female mice are fed a diet rich in methyl groups, the fur pigment of subsequent offspring is permanently altered. Without any change to DNA at all, methyl groups could be added or subtracted, and the changes were inherited much like a mutation in a gene.

Now, at the bar in Madrid, Szyf and Meaney considered a hypothesis as improbable as it was profound: If diet and chemicals can cause epigenetic changes, could certain experiences — child neglect, drug abuse or other severe stresses — also set off epigenetic changes to the DNA inside the neurons of a person’s brain? That question turned out to be the basis of a new field, behavioral epigenetics, now so vibrant it has spawned dozens of studies and suggested profound new treatments to heal the brain.

According to the new insights of behavioral epigenetics, traumatic experiences in our past, or in our recent ancestors’ past, leave molecular scars adhering to our DNA. Jews whose great-grandparents were chased from their Russian shtetls; Chinese whose grandparents lived through the ravages of the Cultural Revolution; young immigrants from Africa whose parents survived massacres; adults of every ethnicity who grew up with alcoholic or abusive parents — all carry with them more than just memories.

Like silt deposited on the cogs of a finely tuned machine after the seawater of a tsunami recedes, our experiences, and those of our forebears, are never gone, even if they have been forgotten. They become a part of us, a molecular residue holding fast to our genetic scaffolding. The DNA remains the same, but psychological and behavioral tendencies are inherited. You might have inherited not just your grandmother’s knobby knees, but also her predisposition toward depression caused by the neglect she suffered as a newborn.

Or not. If your grandmother was adopted by nurturing parents, you might be enjoying the boost she received thanks to their love and support. The mechanisms of behavioral epigenetics underlie not only deficits and weaknesses but strengths and resiliencies, too. And for those unlucky enough to descend from miserable or withholding grandparents, emerging drug treatments could reset not just mood, but the epigenetic changes themselves. Like grandmother’s vintage dress, you could wear it or have it altered. The genome has long been known as the blueprint of life, but the epigenome is life’s Etch A Sketch: Shake it hard enough, and you can wipe clean the family curse.

Voodoo Genetics 

Twenty years after helping to set off a revolution, Meaney sits behind a wide walnut table that serves as his desk. A January storm has deposited half a foot of snow outside the picture windows lining his fourth-floor corner office at the Douglas Institute, a mental health affiliate of McGill. He has the rugged good looks and tousled salt-and-pepper hair of someone found on a ski slope — precisely where he plans to go this weekend. On the floor lays an arrangement of helium balloons in various stages of deflation. “Happy 60th!” one announces.

“I’ve always been interested in what makes people different from each other,” he says. “The way we act, the way we behave — some people are optimistic, some are pessimistic. What produces that variation? Evolution selects the variance that is most successful, but what produces the grist for the mill?”

Meaney pursued the question of individual differences by studying how the rearing habits of mother rats caused lifelong changes in their offspring. Research dating back to the 1950s had shown that rats handled by humans for as little as five to 15 minutes per day during their first three weeks of life grew up to be calmer and less reactive to stressful environments compared with their non-handled littermates. Seeking to tease out the mechanism behind such an enduring effect, Meaney and others established that the benefit was not actually conveyed by the human handling. Rather, the handling simply provoked the rats’ mothers to lick and groom their pups more, and to engage more often in a behavior called arched-back nursing, in which the mother gives the pups extra room to suckle against her underside.

“It’s all about the tactile stimulation,” Meaney says.

In a landmark 1997 paper in Science, he showed that natural variations in the amount of licking and grooming received during infancy had a direct effect on how stress hormones, including corticosterone, were expressed in adulthood. The more licking as babies, the lower the stress hormones as grown-ups. It was almost as if the mother rats were licking away at a genetic dimmer switch. What the paper didn’t explain was how such a thing could be possible.

“What we had done up to that point in time was to identify maternal care and its influence on specific genes,” Meaney says. “But epigenetics wasn’t a topic I knew very much about.”

And then he met Szyf.

Postnatal Inheritance 

“I was going to be a dentist,” Szyf says with a laugh. Slight, pale and balding, he sits in a small office at the back of his bustling laboratory — a room so Spartan, it contains just a single picture, a photograph of two embryos in a womb.

Needing to write a thesis in the late 1970s for his doctorate in dentistry at Hebrew University of Jerusalem, Szyf approached a young biochemistry professor named Aharon Razin, who had recently made a splash by publishing his first few studies in some of the world’s top scientific journals. The studies were the first to show that the action of genes could be modulated by structures called methyl groups, a subject about which Szyf knew precisely nothing. But he needed a thesis adviser, and Razin was there. Szyf found himself swept up to the forefront of the hot new field of epigenetics and never looked back.

Until researchers like Razin came along, the basic story line on how genes get transcribed in a cell was neat and simple. DNA is the master code, residing inside the nucleus of every cell; RNA transcribes the code to build whatever proteins the cell needs. Then some of Razin’s colleagues showed that methyl groups could attach to cytosine, one of the chemical bases in DNA and RNA.

It was Razin, working with fellow biochemist Howard Cedar, who showed these attachments weren’t just brief, meaningless affairs. The methyl groups could become married permanently to the DNA, getting replicated right along with it through a hundred generations. As in any good marriage, moreover, the attachment of the methyl groups significantly altered the behavior of whichever gene they wed, inhibiting its transcription, much like a jealous spouse. It did so, Razin and Cedar showed, by tightening the thread of DNA as it wrapped around a molecular spool, called a histone, inside the nucleus. The tighter it is wrapped, the harder to produce proteins from the gene.

Consider what that means: Without a mutation to the DNA code itself, the attached methyl groups cause long-term, heritable change in gene function. Other molecules, called acetyl groups, were found to play the opposite role, unwinding DNA around the histone spool, and so making it easier for RNA to transcribe a given gene.

By the time Szyf arrived at McGill in the late 1980s, he had become an expert in the mechanics of epigenetic change. But until meeting Meaney, he had never heard anyone suggest that such changes could occur in the brain, simply due to maternal care.

“It sounded like voodoo at first,” Szyf admits. “For a molecular biologist, anything that didn’t have a clear molecular pathway was not serious science. But the longer we talked, the more I realized that maternal care just might be capable of causing changes in DNA methylation, as crazy as that sounded. So Michael and I decided we’d have to do the experiment to find out.”

Actually, they ended up doing a series of elaborate experiments. With the assistance of postdoctoral researchers, they began by selecting mother rats who were either highly attentive or highly inattentive. Once a pup had grown up into adulthood, the team examined its hippocampus, a brain region essential for regulating the stress response. In the pups of inattentive mothers, they found that genes regulating the production of glucocorticoid receptors, which regulate sensitivity to stress hormones, were highly methylated; in the pups of conscientious moms, the genes for the glucocorticoid receptors were rarely methylated.

Methylation just gums up the works. So the less the better when it comes to transcribing the affected gene. In this case, methylation associated with miserable mothering prevented the normal number of glucocorticoid receptors from being transcribed in the baby’s hippocampus. And so for want of sufficient glucocorticoid receptors, the rats grew up to be nervous wrecks.

To demonstrate that the effects were purely due to the mother’s behavior and not her genes, Meaney and colleagues performed a second experiment. They took rat pups born to inattentive mothers and gave them to attentive ones, and vice versa. As they predicted, the rats born to attentive mothers but raised by inattentive ones grew up to have low levels of glucocorticoid receptors in their hippocampus and behaved skittishly. Likewise, those born to bad mothers but raised by good ones grew up to be calm and brave and had high levels of glucocorticoid receptors.

Before publishing their findings, Meaney and Szyf conducted a third crucial experiment, hoping to overwhelm the inevitable skeptics who would rise up to question their results. After all, it could be argued, what if the epigenetic changes observed in the rats’ brains were not directly causing the behavioral changes in the adults, but were merely co-occurring? Freud certainly knew the enduring power of bad mothers to screw up people’s lives. Maybe the emotional effects were unrelated to the epigenetic change.

To test that possibility, Meaney and Szyf took yet another litter of rats raised by rotten mothers. This time, after the usual damage had been done, they infused their brains with trichostatin A, a drug that can remove methyl groups. These animals showed none of the behavioral deficits usually seen in such offspring, and their brains showed none of the epigenetic changes.

“It was crazy to think that injecting it straight into the brain would work,” says Szyf. “But it did. It was like rebooting a computer.”

Despite such seemingly overwhelming evidence, when the pair wrote it all up in a paper, one of the reviewers at a top science journal refused to believe it, stating he had never before seen evidence that a mother’s behavior could cause epigenetic change.

“Of course he hadn’t,” Szyf says. “We wouldn’t have bothered to report the study if it had already been proved.”

In the end, their landmark paper, “Epigenetic programming by maternal behavior,” was published in June 2004 in the journal Nature Neuroscience.

Meaney and Szyf had proved something incredible. Call it postnatal inheritance: With no changes to their genetic code, the baby rats nonetheless gained genetic attachments due solely to their upbringing — epigenetic additions of methyl groups sticking like umbrellas out the elevator doors of their histones, gumming up the works and altering the function of the brain.

The Beat Goes On

Together, Meaney and Szyf have gone on to publish some two-dozen papers, finding evidence along the way of epigenetic changes to many other genes active in the brain. Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney’s lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain. When those babies grow up, the resulting decrease of estrogen receptors makes them less attentive to their babies. And so the beat goes on.

As animal experiments continue apace, Szyf and Meaney have entered into the next great step in the study of behavioral epigenetics: human studies. In a 2008 paper, they compared the brains of people who had committed suicide with the brains of people who had died suddenly of factors other than suicide. They found excess methylation of genes in the suicide brains’ hippocampus, a region critical to memory acquisition and stress response. If the suicide victims had been abused as children, they found, their brains were more methylated.

Why can’t your friend “just get over” her upbringing by an angry, distant mother? Why can’t she “just snap out of it”? The reason may well be due to methyl groups that were added in childhood to genes in her brain, thereby handcuffing her mood to feelings of fear and despair.

Of course, it is generally not possible to sample the brains of living people. But examining blood samples in humans is routine, and Szyf has gone searching there for markers of epigenetic methylation. Sure enough, in 2011 he reported on a genome-wide analysis of blood samples taken from 40 men who participated in a British study of people born in England in 1958.

All the men had been at a socioeconomic extreme, either very rich or very poor, at some point in their lives ranging from early childhood to mid-adulthood. In all, Szyf analyzed the methylation state of about 20,000 genes. Of these, 6,176 genes varied significantly based on poverty or wealth. Most striking, however, was the finding that genes were more than twice as likely to show methylation changes based on family income during early childhood versus economic status as adults.

Timing, in other words, matters. Your parents winning the lottery or going bankrupt when you’re 2 years old will likely affect the epigenome of your brain, and your resulting emotional tendencies, far more strongly than whatever fortune finds you in middle age.

Last year, Szyf and researchers from Yale University published another study of human blood samples, comparing 14 children raised in Russian orphanages with 14 other Russian children raised by their biological parents. They found far more methylation in the orphans’ genes, including many that play an important role in neural communication and brain development and function.

“Our study shows that the early stress of separation from a biological parent impacts long-term programming of genome function; this might explain why adopted children may be particularly vulnerable to harsh parenting in terms of their physical and mental health,” said Szyf’s co-author, psychologist Elena Grigorenko of the Child Study Center at Yale. “Parenting adopted children might require much more nurturing care to reverse these changes in genome regulation.”

A case study in the epigenetic effects of upbringing in humans can be seen in the life of Szyf’s and Meaney’s onetime collaborator, Frances Champagne. “My mom studied prolactin, a hormone involved in maternal behavior. She was a driving force in encouraging me to go into science,” she recalls. Now a leading figure in the study of maternal influence, Champagne just had her first child, a daughter. And epigenetic research has taught her something not found in the What to Expect books or even her mother’s former lab.

“The thing I’ve gained from the work I do is that stress is a big suppressor of maternal behavior,” she says. “We see it in the animal studies, and it’s true in humans. So the best thing you can do is not to worry all the time about whether you’re doing the right thing. Keeping the stress level down is the most important thing. And tactile interaction — that’s certainly what the good mother rats are doing with their babies. That sensory input, the touching, is so important for the developing brain.”

The Mark Of Cain 

The message that a mother’s love can make all the difference in a child’s life is nothing new. But the ability of epigenetic change to persist across generations remains the subject of debate. Is methylation transmitted directly through the fertilized egg, or is each infant born pure, a methylated virgin, with the attachments of methyl groups slathered on solely by parents after birth?

Neuroscientist Eric Nestler of the Icahn School of Medicine at Mount Sinai in New York has been seeking an answer for years. In one study, he exposed male mice to 10 days of bullying by larger, more aggressive mice. At the end of the experiment, the bullied mice were socially withdrawn.

To test whether such effects could be transmitted to the next generation, Nestler took another group of bullied mice and bred them with females, but kept them from ever meeting their offspring.

Despite having no contact with their depressed fathers, the offspring grew up to be hypersensitive to stress. “It was not a subtle effect; the offspring were dramatically more susceptible to developing signs of depression,” he says.

In further testing, Nestler took sperm from defeated males and impregnated females through in vitro fertilization. The offspring did not show most of the behavioral abnormalities, suggesting that epigenetic transmission may not be at the root. Instead, Nestler proposes, “the female might know she had sex with a loser. She knows it’s a tainted male she had sex with, so she cares for her pups differently,” accounting for the results.

Despite his findings, no consensus has yet emerged. The latest evidence, published in the Jan. 25 issue of the journal Science, suggests that epigenetic changes in mice are usually erased, but not always. The erasure is imperfect, and sometimes the affected genes may make it through to the next generation, setting the stage for transmission of the altered traits in descendants as well.

What’s Next?

The studies keep piling on. One line of research traces memory loss in old age to epigenetic alterations in brain neurons. Another connects post-traumatic stress disorder to methylation of the gene coding for neurotrophic factor, a protein that regulates the growth of neurons in the brain.

If it is true that epigenetic changes to genes active in certain regions of the brain underlie our emotional and intellectual intelligence — our tendency to be calm or fearful, our ability to learn or to forget — then the question arises: Why can’t we just take a drug to rinse away the unwanted methyl groups like a bar of epigenetic Irish Spring?

The hunt is on. Giant pharmaceutical and smaller biotech firms are searching for epigenetic compounds to boost learning and memory. It has been lost on no one that epigenetic medications might succeed in treating depression, anxiety and post-traumatic stress disorder where today’s psychiatric drugs have failed.

But it is going to be a leap. How could we be sure that epigenetic drugs would scrub clean only the dangerous marks, leaving beneficial — perhaps essential — methyl groups intact? And what if we could create a pill potent enough to wipe clean the epigenetic slate of all that history wrote? If such a pill could free the genes within your brain of the epigenetic detritus left by all the wars, the rapes, the abandonments and cheated childhoods of your ancestors, would you take it?

Retrieved from: http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes#.UxPna_RdXWo

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Integrative Healing Workshops January 26, 2014

Posted by Dreamhealer in Alternative medicine, Dreamhealer, Energy Healing, Healing, Health, Workshops.
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Adam Dreamhealer holds ‘Integrative Healing workshops‘ around the world promoting what he sees as the most overlooked aspect in preventative health care today: involving the patient in their own health care by using their focused healing intentions. At his workshop events, participants experience self-empowerment as Adam merges the auras of all present and performs two unique group energy treatments. He gives everyone present, the tools to activate their own innate healing power. Forty percent of those who attend Adam’s one-day workshops are healthcare professionals learning how to integrate Adam’s techniques into their practices. Rolling Stone Magazine calls Adam “One of the world’s most in-demand healers”.

Adam Dreamhealer is a graduate in Molecular Biology and biochemistry, healer, best-selling author, speaker and teacher of self-empowerment. It is well known that a positive attitude promotes healing. This knowledge is a basic survival instinct and just needs to be activated in order to maximize its effect. From a very young age it is accepted that intention is an important factor in any healing process. Medical communities in cultures all around the world have known for thousands of years that a focused positive patient is more likely to heal. Adam Dreamhealer emphasizes this at each of his workshops, in his books and DVD as the most powerful, yet overlooked preventative aspect of medicine.

In the 1950’s when Watson and Crick solved the structure of DNA things suddenly changed. The scientific community became obsessed with finding a structural biochemical explanation for every biological event. As technology advanced it seemed that every mystery in biology could be explained by physical chemical interactions. In 2003 the human genome was sequenced and at that time this was thought to be the final frontier in molecular biology, which would leave few remaining mysteries in biology.

Rather than solving all biological questions, it was realized that there are many important mechanisms that are poorly understood. Stem cells are particularly effective at highlighting some key concepts that remain unknown. Every cell in a person’s body carries the exact same genetic information, yet the brain cells look and function dramatically different than skin cells. How is this possible?

It turns out that there are proteins that associate with the DNA and it is these proteins that determine which genes are “turned on” and which ones are not. It is this selective control of the DNA that results in these cells having completely different properties. These discoveries resulted in the development of a new field of study known as epigenetics. This has dramatically changed our understanding of biology as epigenetics established that environment has a significant and detectable impact on changes in every cell in the body, and every protein.

With regards to healing this is important because proteins are incredibly sensitive to their environment. The slightest change in the environment results in significant changes to these proteins, which consequently influence every aspect of the cell metabolism. When someone is trying to improve his or her health, regardless of what the medical condition is, the goal is to change cell metabolism such that balance can once again be restored.

A crucial factor in the environment is how a person chooses to perceive their environment. It is certainly evident that the human body reacts differently when relaxed as opposed to when stressed or tensed. If a situation is perceived to be positive and ideal for healing then this changes the environment within the body. This directly influences cellular events and consequently health.

Human cells are no longer considered to be complex biochemical machines that function solely on chemical and physical interactions. It is important to remember that cells are conscious organisms that do everything possible to maximize their contribution to health and wellbeing. Every cell in the body is functioning together for the benefit of the whole organism. This knowledge is very empowering because everyone has the power to influence every biochemical event that occurs in the body.

Finally molecular biology is beginning to confirm what has been known to be true for thousands of years, that our intentions influence our health. So take the time to clear your mind and talk with your cells because they are certainly listening to what you have to say.

To register for an upcoming workshop click here 

Integrative Healing Workshop – Seattle, WA- March 8, 2014 

Integrative Healing Workshop – Los Angeles, CA – April 5, 2014

Integrative Healing Workshop – Winnipeg, Manitoba – June 7, 2014

Integrative Healing Workshop – Ottawa, Ontario – September 13, 2014

Integrative Healing Workshop – Toronto, Ontario – September 14, 2014

Integrative Healing Workshop -Calgary, Alberta – September 20, 2014

Integrative Healing Workshop -Vancouver, British Columbia – October 5, 2014

Sleeping It Off: How Alcohol Affects Sleep Quality March 15, 2013

Posted by Dreamhealer in Alcohol, Experiments, Health, Research, Sleep.
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drinking affects sleep dreamhealer

Having a drink (or two) is one way to nod off more quickly, but how restful is an alcohol-induced slumber?

The latest research, published in Alcoholism: Clinical and Experimental Research, shows that while a nightcap may get you to doze off, you’re more likely to wake up during the night and may not feel as rested following your sleep.

Scientists reviewed 20 studies that included 517 participants who were tested in 38 sleep laboratory experiments. The volunteers drank varying amounts of alcohol, ranging from a low of one to two drinks, a moderate amount of two to four drinks, to a high of four or more drinks. While some experiments examined the results of only one night of drinking, others extended into several consecutive nights. Most of the participants were healthy young adults, and none had drinking problems.

“This review confirms that the immediate and short-term impact of alcohol is to reduce the time it takes to fall asleep,” lead author of the study Irshaad Ebrahim, director of the London Sleep Center, said in a statement. “In addition, the higher the dose, the greater the impact on increasing deep sleep.”This helps explain why so many people rely on alcohol to fall asleep, despite warnings from experts that it merely postpones and can worsen insomnia. “The effect of consolidating sleep in the first half of the night is offset by having more disrupted sleep in the second half of the night,” Ebrahim said.That presents a more complicated picture of how alcohol affects sleep, and the trade-off may have implications for understanding how sleep can impact overall health as well. At all doses studied, alcohol increased deep or so-called slow-wave sleep (SWS) during the first part of the night. This type of slumber is associated with healing and regeneration of bones, muscles and other tissues, as well as maintaining a strong immune system.“SWS or deep sleep generally promotes rest and restoration,” Ebrahim said, cautioning, however, that alcohol increases in this stage can worsen sleep apnea and sleepwalking in people who are prone to those problems.

In contrast, drinking has long been known to reduce REM sleep, the deepest sleep stage in which most dreams occur and during which memories are likely stored and learning occurs. And the current review suggests that it’s the amount of alcohol people drink that may have the biggest effect on their sleep quality. One or two drinks, for example, can increase slow-wave sleep while not affecting deeper REM sleep. But more alcohol can cut into the time spent in the REM stage. So that nightcap may be helpful in getting you to doze off, while a wild night of heavy drinking is likely to make you more restless. Moderation, it seems, is the key to a good night’s sleep.

Article retrieved from: http://www.healthland.time.com
To read more about my work visit my websitehttp://dreamhealer.com/

Adam’s 2013 workshop schedule has been announced. Click here to see a list of upcoming workshops.

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Emotions March 11, 2013

Posted by Dreamhealer in Alternative medicine, Books, Dreamhealer, Emotion, Energy Healing, Healing, Health.
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adam the healer

Everyone reacts differently to events and experiences. Everyone experiences a range between happy and sad emotions. It is healthy to have a range of emotions. However, habitual negative feelings often contribute to physical illness. Many people whom I have worked on have a very strong emotional component to their physical ailment. In a great number of cases, the source of the problem is emotional: The health challenge is the physical manifestation of emotional baggage.

Just as emotions can intensify a health problem, they can also be used to alleviate many issues. Use your intentions to guide your emotions for the betterment of your health. I have noticed that some people who attend my workshops show signs of depression. The physical ailment may be at the root of the depression, or physical symptoms may be manifesting as a result of depression. Whichever the case may be, depression is intertwined with one’s emotions and emotions are inseparable from the physical body. It is important to realize that we can influence emotions and our reactions to them. Rather than spending time trying to decided which challenge appeared first, use energy to improve your state of mental and physical well-being.

Taken from Adam’s third book, The Path of the Dreamhealer.

Visit the online bookstore here.

Adam’s 2013 workshop schedule has been announced. Click here to see a list of upcoming workshops.

Like me on facebook

Follow me on twitter and pinterest

All my video blogs can be found on my YouTube page. For a directory of video blogs, click here.

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