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Naturopathic Doctors – Medically Trained, but Naturally Focused. June 23, 2016

Posted by Dreamhealer in best vancouver naturopath, Healing, Naturopathic Doctor, Naturopathic Medicine, Supplements.
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As we celebrate the advances that naturopathic medicine has been making, we also have to acknowledge the recent negativity being directed at our profession from certain groups within the medical world and their media minions. A recent tragic case in Alberta saw a couple being convicted of failing to provide the necessities of life for their young son, who died of bacterial meningitis in 2012. Over the course of this case, it was revealed that they had contacted one of our Alberta naturopathic doctors by phone, who had instructed her staff to tell them to take the child to seek emergency medical care. The next day, someone (who later turned out to be a member of the same family) came into her clinic to purchase an herbal immune support formula, something that would commonly be available over the counter at any number of natural pharmacies across Canada. However, subsequent to this, a group of Alberta medical doctors took it upon themselves to call for an investigation into the actions of the ND – the same ND who didn’t see the child, didn’t provide any medical advice other than to go to the ER, and didn’t provide any treatment.

Similarly, our friends at the Globe and Mail have been very active in displaying their bias against safe, natural medicine, doing their best to misrepresent facts to distort the truth. This brings to mind a CBC Marketplace “investigation” from a few years back, that claimed to answer once and for all, whether homeopathy was an effective health care modality. Luckily, they made it perfectly obvious that they didn’t consult a single person with any knowledge or training in homeopathy, as they designed their “study” in such a way as to render it utterly useless. An analogy I could make – if they took a prescription sleep aid, rubbed it on their forehead, then went to bed with it under their pillow – then came to the “scientific” conclusion that it didn’t work.

But most alarming was this editorial penned by Peter McKnight, a journalist whose training in anything medically related extends to an undergraduate degree in psychology. He attempts to convince his readers that Western medicine long ago threw out the notion of the “healing power of nature”, implying that the only thing standing in the way of the certain annihilation of the human race by disease is an army of white-coated medical doctors armed with their trusty prescription pads. If you find me one doctor who tells you that the human body doesn’t have the ability to heal itself, I’ll show you a doctor who is either ignorant or lying. Everyone (including every parent in the world) knows that the body will heal itself, as long as you remove whatever factor is in the way of that. And in fact – if that vis medicatrix naturae isn’t present, nothing any doctor does will have any effect on actually healing a patient, save for keeping them alive. If your kid scrapes his knee – you clean it well, keep it clean, and keep your child from picking at the obviously fascinating scab that will form – and it will heal. On its own. Extend that to a multitude of illnesses, and you’ll find that once you remove the obstacles to health (poor diet and lifestyle, lack of sleep, nutritional deficits, chronic assault from environmental toxins, stress, etc), for the most part, patients will return to a state of health.

A common complaint about naturopathic medicine is around safety and efficacy. They say that manufacturers of natural supplements aren’t required to demonstrate efficacy to Health Canada before having them approved for sale. But they are required to demonstrate safety. With regards to safety, I’m not aware of a single case of a patient dying as a result of any medical intervention by a licensed naturopathic doctor. Compare that to the statistic that medical error is now the third-leading cause of death in the US. Let he who is without a single dead patient cast the first stone, I say.

Regarding efficacy – let’s break this down a little. For medical doctors accustomed to using pharmaceuticals to force the body back into line, they typically see results on the order of days to a few weeks. If there’s no clear benefit in that time, you can conclude the treatment is ineffective. Applying that same quantifier to natural remedies is like comparing apples to oranges. As stated earlier, naturopathic medicine focuses on encouraging a return to health, through (for the most part) gentle interventions that gradually shift the body’s health on both a physical and energetic level. Most people I see have spent years or even decades gradually getting to their current state of ill health. Any intervention that claims to return them to health in a few days will not work, simply because once the medication is discontinued, the body will revert to the state to which it has become accustomed.

Furthermore, if you equate the efficacy of a treatment to a cure, we must consider how many classes of drugs actually purport to “cure” anything”. One notable exception would be antimicrobials for a bacterial or fungal infection. Go beyond that, and the cure rate drops significantly. Anti-depressants only work as long as people remain on the medication (assuming they work at all, or don’t make the condition worse). Statins artificially lower cholesterol levels, which return to pre-treatment levels upon discontinuation of the drug. Same with medications for high blood pressure, stomach acid levels, sleep and anxiety, the list goes on. Until the obstacles to health are removed, health will not be achieved.

In this, the stark difference between naturopathic doctors and medical doctors – the question “why?”. Why are these symptoms occurring? Naturopathic doctors aim to find and treat the cause of illness, rather than simply playing whack-a-mole with symptoms by prescribing one medication after another, often to simply treat the side effects created by the original drug.

So in conclusion, happy Naturopathic Medicine Week, to the tens of thousands of happy and healthy patients across Canada who attribute their good health to their naturopathic care, and to the growing group of allies within the conventional medical community – modern doctors and nurses who recognize the benefit to patients of collaborative and complementary medicine. To the rest of you – the dinosaurs who continue their desperate campaign to convince the public that you’ve got all the answers, that pharmaceuticals are the only way to go, and that under no circumstances, should they ever ask you “why” – it’s not too late to join the right side of history. The future of medicine will be found in the middle ground, currently populated with medically-focused naturopathic doctors and medical doctors practicing what they’ve termed “functional medicine” – where through a mixture of modern innovation and traditional healing we create a paradigm of health – instead of treating disease.

Naturopathic doctors – Medically Trained, but Naturally Focused.

In Health,

Dr. Reuben Dinsmore, ND

http://www.theglobeandmail.com/opinion/message-to-naturopaths-magic-isnt-medicine/article29929971/

Is the Alkaline Diet an Effective Cancer Treatment? September 11, 2014

Posted by Dreamhealer in Healing.
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Cancer food

Every day I see cancer patients who are drinking alkaline water and focusing a significant amount of their time and energy on alkaline foods. Is this an effective cure for cancer? The short answer is no and any observed positive effects have nothing to do with the foods being alkaline. Let me explain why this is.

In the early 20th century it was observed that cancer cells could not grow in alkaline environments. There are a number of metabolic reasons why this is and this principle is very effective in a petri dish. The problem is that this theory simply does not apply to our bodies. The pH is a measure of how acid or basic a liquid is. You cannot change the pH of your blood enough to influence cancer. To understand why, you need to look at the biochemistry of the blood.

Our blood is buffered which means that it is absolutely full of molecules that make sure there are no variations in the pH of the blood. The body spends a substantial amount of energy keeping the pH of the blood with in a very narrow range. Every single protein in your entire body is designed to work at a very specific pH. If there is any deviation from this optimal pH then the protein ceases to function properly. In other words, if you were able to make your blood significantly more basic it would very quickly result in kidney failure, respiratory failure and ultimately death. Our cells have been adapting to a very narrow pH range for millions of years and there are many metabolic reasons for this. When you drink alkaline water and eat alkaline foods it does not make your blood alkaline.

Any positive studies relating to the alkaline diet have nothing to do with the foods being alkaline. When you look at the list of “alkaline foods” it consists mostly of fresh fruit, vegetables, nuts and legumes with very small amounts of meat. These are all very healthy foods that are rich in nutrients. The high nutrient content is completely unrelated to the alkaline nature of these foods.

When designing an ideal diet plan for cancer patients the first goal is making sure they are getting adequate nutrients because the cells will have increased metabolic demands while fighting cancer. The second goal is making sure that they are avoiding foods that are rich in sugar. Very often this diet will consist of fresh fruits, vegetables, nuts and legumes. No one disputes that these foods are helpful when combating cancer but it is clear that this positive effect from these foods is not due to them being alkaline.

If you are fighting cancer it is essential that you have professional guidance with your diet. Before you make any dramatic changes contact a Naturopathic physician that works with oncology. A Naturopathic doctor that works with oncology will take the time to look at your case and will design a specific diet plan for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

By: Dr. Adam McLeod, ND, BSc

Mistletoe the parasite July 16, 2014

Posted by Dreamhealer in Cancer, Dreamhealer, Health, Integrative Medicine, Research.
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Mistletoe therapy is emerging as a potent cancer therapy

Mistletoe therapy is emerging as a potent cancer therapy

Mistletoe is a parasitic plant that directly derives almost all of its nutrition from other flowering plants. By parasitizing other plants, they have a competitive advantage over many other forms of life because they do not have to compete in soil for their water and nutrient needs. This description of mistletoe sounds surprisingly similar to how cancer operates. When you look at mistletoe growing on a tree it looks very much like a tumour. Cancer gets all of its nutrition from other cells within the human body and it has a competitive advantage because it does not abide by the same rules as other cells in the body.

It turns out the mistletoe can be used to effectively treat cancer, even in advanced cases1,2,3. In North America this is often considered a “fringe treatment” yet if you go to Germany this is a mainstream therapy that is well established by the scientific community. The use of mistletoe dramatically reduces the side effects associated with chemotherapy and radiation. The effects are so dramatic that some countries have already made this the standard of care for cancer treatment. The use of mistletoe as the new standard of care was of huge financial benefit to these countries because of the significant decrease in complications from chemotherapy and radiation.

Although there are several different ways to administer mistletoe, the most common is regular subcutaneous injections. This involves the use of small insulin needles and injecting the mistletoe just under the skin. After injecting the mistletoe lectins the immune system immediately begins to attack the injected fluid resulting in a small red rash around the injection site. This immune activation is an excellent outcome in the context of cancer. By activating the immune system at the site of injection it consequently activates the immune system in the entire body.

Mistletoe has been shown to stimulate increases in the number and the activity of several types of white blood cells4. Immune-system-enhancing cytokines, such as interleukin-1, interleukin-6, and tumor necrosis factor -alpha, are released by white blood cells after exposure to mistletoe extracts5,6. Other evidence suggests that mistletoe exerts its cytotoxic effects by interfering with protein synthesis in target cells and by inducing apoptosis7.

Just like any cancer therapy it is essential that it is used in the right context. When this therapy is used there will initially be a swelling of the tumour, this is a consequence of the immune activation. If there are any detectable masses contained within the skull, then clearly swelling is not desirable. Mistletoe therapy is contraindicated in patients that have any detectable mass in the brain. It also must be used with caution on patients that are are cachexic and malnourished. The sudden release of cytokines associated with immune activation can worsen the malnourished state.

Mistletoe therapy only costs approximately $250 dollars per month and it can be used in conjunction with other medical therapies. I regularly use mistletoe with my patients at the clinic and it is an effective cancer therapy when used appropriately. On a regular basis I see patients improve when they use this therapy as part of a comprehensive integrative cancer therapy. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

 

References:

1. Mistletoe. In: Murray MT: The Healing Power of Herbs. Roseville, Calif: Prima Publishing, 1995, pp 253-9.

2. Samtleben R, Hajto T, Hostanska K, et al.: Mistletoe lectins as immunostimulants (chemistry, pharmacology and clinic). In: Wagner H, ed.: Immunomodulatory Agents from Plants. Basel, Switzerland: Birkhauser Verlag, 1999, pp 223-41.

3. Hajto T, Lanzrein C: Natural killer and antibody-dependent cell-mediated cytotoxicity activities and large granular lymphocyte frequencies in Viscum album-treated breast cancer patients. Oncology 43 (2): 93-7, 1986.

4. Büssing A, Regnery A, Schweizer K: Effects of Viscum album L. on cyclophosphamide-treated peripheral blood mononuclear cells in vitro: sister chromatid exchanges and activation/proliferation marker expression. Cancer Lett 94 (2): 199-205, 1995.

5. Hajto T: Immunomodulatory effects of iscador: a Viscum album preparation. Oncology 43 (Suppl 1): 51-65, 1986.

6. Hajto T, Hostanska K, Frei K, et al.: Increased secretion of tumor necrosis factors alpha, interleukin 1, and interleukin 6 by human mononuclear cells exposed to beta-galactoside-specific lectin from clinically applied mistletoe extract. Cancer Res 50 (11): 3322-6, 1990.

7. Mengs U, Schwarz T, Bulitta M, et al.: Antitumoral effects of an intravesically applied aqueous mistletoe extract on urinary bladder carcinoma MB49 in mice. Anticancer Res 20 (5B): 3565-8, 2000 Sep- Oct.

When is high dose IV Vitamin C indicated? June 22, 2014

Posted by Dreamhealer in Cancer, Chemotherapy, Health, Integrative Medicine, Naturopathic Medicine, vitamins.
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High dose IV Vitamin C is emerging as a powerful cancer therapy

By: Dr. Adam McLeod, ND

High dose intravenous Vitamin C has gained a lot of attention in the media lately as an anti-cancer therapy. There is no doubt that when used appropriately this can be an effective integrative cancer therapy1. As the evidence mounts, mainstream medicine is slowly beginning to embrace high dose IV Vitamin C.

Oncologists will frequently tell their patients to fear antioxidants because they will neutralize the effects of the chemotherapy. The rationale is that chemotherapy works by adding oxidative stress to cancer cells and antioxidants will neutralize this effect. On an intuitive level this makes sense but the majority of the scientific evidence indicates that when used appropriately antioxidants protect healthy cells without interfering with the effects of the chemotherapy2,3.

It is important to point out that Vitamin C is not an antioxidant when given at high doses intravenously4. When taken orally at low doses Vitamin C is an effective antioxidant and it has many positive benefits. At high doses Vitamin C switches roles and acts as a potent oxidative molecule, which is the complete opposite of its antioxidant role at lower doses. Studies show that at high doses Vitamin C is very toxic to cancer cells6. In this cellular context it is a potent oxidative molecule that works synergistically with most conventional therapies.

Patients who undergo this therapy tend to experience less significant side effects from the chemotherapy7,8. IV Vitamin C can vastly improve quality of life by increasing appetite, raising platelet counts, easing fatigue and reducing pain. When patients are supported by the appropriate nutrients and supplements, the side effects from chemotherapy are less intense. Studies consistently show that at these high doses, Vitamin C is toxic to cancer cells while protecting healthy cells from the effects of chemotherapy. The evidence indicates that IV Vitamin C is effective when used in conjunction with chemotherapy rather than as a stand alone therapy.

There are several different situations where high dose IV Vitamin C is not safe. Although it is safe to use with most chemotherapies, it is not safe to use with Velcade (Bortezomib)5. There are a number of studies that show a negative interaction between this particular drug and Vitamin C. When injecting Vitamin C there is a significant amount of sodium that is in the infusion and this can add a significant burden to the kidneys. This stress to the kidneys is only a concern in patients that have significantly compromised kidney function. There is also a rare genetic condition known as G6PD and in these patients it is not safe to give them high doses of Vitamin C. You need an experienced health care professional to assess your health history and ensure that you do not have any contraindications to this therapy.

I regularly run IV Vitamin C on my patients at the clinic and it is a very effective cancer therapy when used appropriately. On a regular basis I see patients improve significantly when they use this therapy as part of a comprehensive integrative cancer therapy. Contact Yaletown Naturopathic Clinic to see if this is the right therapy for you.

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

 

References:

1) Vollbracht, Claudia, et al. “Intravenous vitamin C administration improves quality of life in breast cancer patients during chemo-/radiotherapy and aftercare: results of a retrospective, multicentre, epidemiological cohort study in Germany.” in vivo 25.6 (2011): 983-990.

2) Suhail, N., et al. “Effect of vitamins C and E on antioxidant status of breast‐cancer patients undergoing chemotherapy.” Journal of clinical pharmacy and therapeutics 37.1 (2012): 22-26.

3) Tabassum, A., R. G. Bristow, and V. Venkateswaran. “Ingestion of selenium and other antioxidants during prostate cancer radiotherapy: a good thing?.” Cancer treatment reviews36.3 (2010): 230-234.

4) Carr, Anitra, and Balz Frei. “Does vitamin C act as a pro-oxidant under physiological conditions?.” The FASEB Journal 13.9 (1999): 1007-1024.

5) Perrone, G., et al. “Ascorbic acid inhibits antitumor activity of bortezomib in vivo.” Leukemia23.9 (2009): 1679-1686.

6) Riordan, N. H., et al. “Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent.”Medical hypotheses 44.3 (1995): 207-213.

7) Weijl, N. I., et al. “Supplementation with antioxidant micronutrients and chemotherapy-induced toxicity in cancer patients treated with cisplatin-based chemotherapy: a randomised, double-blind, placebo-controlled study.” European Journal of Cancer 40.11 (2004): 1713-1723.

8) Takemura, Yukitoshi, et al. “High dose of ascorbic acid induces cell death in mesothelioma cells.” Biochemical and biophysical research communications 394.2 (2010): 249-253.

Heat: The Achilles Heel of Cancer June 2, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Dreamhealer, Healing, Health, Integrative Medicine, naturopathic, Naturopathic Medicine, Naturopathy, Prostate Cancer, Research.
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Heat: The Achilles Heel of Cancer

Written By: Dr. Adam McLeod, ND

It is a well established fact that cancer cells are vulnerable to heat1,2. On a cellular level it makes intuitive sense that cancer cells would be sensitive to heat. Normal cells are spatially arranged so that heat can be distributed evenly and they will not divide if they are physically in contact with adjacent cells. Cancer cells within a tumour will continue to divide regardless of the proximity of adjacent cells; this is one of the hallmarks of cancer. As a result of this uncontrolled growth, the cells in the tumour become densely packed together and this makes it very difficult for them to effectively distribute heat.

Hyperthermia treatment is rapidly becoming a mainstream therapy for patients undergoing chemotherapy and radiation. During these treatments the patients’ core body temperature is artificially raised to mimic a strong fever. This is not a pleasant experience for the patient but it is very effective at weakening the cancer cells. It makes these cancer cells more vulnerable to chemotherapy and radiation.

When any cell is exposed to heat there are immediate biochemical and genetic changes that occur so that the cell can adapt to the new warm environment. One of the most potent responses that allows these cells to survive the heat is the production of heat shock proteins (HSP)3. These HSPs protect components within the cell that are vulnerable to heat damage and during hyperthermia the production of these proteins within cancer cells is what allows them to survive. Currently there is a major push with pharmaceutical companies to develop drugs that inhibit these proteins.

There are several different natural compounds which are well documented heat shock protein inhibitors. These substances are safe when used in the right clinical context and you need to consult a Naturopathic Doctor to know if this is the best therapy for that specific type of cancer. One example is Quercetin, a bioflavonoid that is well documented as a potent inhibitor of heat shock proteins in cancer cells4,5,6,7,8,9.

Cancer cells are naturally very vulnerable to heat based on how densely the cells are packed together. When hyperthermia is combined with Quercetin the results are very dramatic10. In one study on prostate carcinoma they concluded that, “When combined in a treatment protocol with hyperthermia, Quercetin drastically inhibited tumour growth and potently amplified the effects of hyperthermia on two prostate tumour types, PC-3 and DU-145 in vivo. These experiments, thus, suggest the use of Quercetin as a hyperthermia sensitizer in the treatment of prostate carcinoma.”

It is extremely important to point out two things. Firstly, Quercetin is safe with most but not all chemotherapy drugs and you need professional guidance from a Naturopathic Doctor who focuses in oncology to know if this is safe for you. Secondly, the quality of the Quercetin supplement makes a big difference. Generally speaking Quercetin is very poorly absorbed and there are only a few professional brands of sufficient quality that are effective at sensitizing the cancer cells. In some cases, intravenous Quercetin is more appropriate.

The mainstream medical community is changing its tune with regards to hyperthermia. In private hospitals in the United States it is very commonly used because it is so effective. In Canada, there are only a handful of clinics that currently offer this therapy. As the evidence for this therapy accumulates, in the near future hyperthermia combined with these natural approaches will undoubtedly become the standard of care for cancer patients.

 

Dr. Adam McLeod is a Naturopathic Doctor (ND), BSc. (Hon) Molecular biology, First Nations Healer, Motivational Speaker and International Best Selling Author. He currently practices at his clinic in Vancouver, British Columbia where he focuses on integrative oncology. http://www.yaletownnaturopathic.com

References:

1. Van der Zee J. Heating the patient: a promising approach? Ann Oncol, 2002. 13(8): p. 1173-84.

2. Van der Zee J and MC Erasmus. Hyperthermia in addition to radiotherapy. Clin Oncol (R Coll Radiol), 2007. 19(3 Suppl): S18.

3. De Maio A (January 1999). “Heat shock proteins: facts, thoughts, and dreams”. Shock (Augusta, Ga.) 11 (1):1-12.

4.  Hansen, R. K., et al. “Quercetin inhibits heat shock protein induction but not heat shock factor DNA-binding in human breast carcinoma cells.” Biochemical and biophysical research communications 239.3 (1997): 851-856.

5. Gonzalez, Oscar, et al. “The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production.” Hepatology 50.6 (2009): 1756-1764.

6. Wei, Yu-quan, et al. “Induction of apoptosis by quercetin: involvement of heat shock protein.” Cancer Research 54.18 (1994): 4952-4957.

7. Zanini, Cristina, et al. “Inhibition of heat shock proteins (HSP) expression by quercetin and differential doxorubicin sensitization in neuroblastoma and Ewing’s sarcoma cell lines.” Journal of neurochemistry 103.4 (2007): 1344-1354.

8. Hosokawa, Nobuko, et al. “Flavonoids inhibit the expression of heat shock proteins.” Cell structure and function 15.6 (1990): 393-401.

9. Elia, Guiliano, and M. G. Santoro. “Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells.” Biochem. J 300 (1994): 201-209.

10. Asea, A., et al. “Effects of the flavonoid drug quercetin on the response of human prostate tumours to hyperthermia in vitro and in vivo.” International journal of hyperthermia 17.4 (2001): 347-356.

 

Seeing your Doctor to Prevent Illness April 11, 2014

Posted by Dreamhealer in Alternative medicine, Cancer, Dreamhealer, Energy Healing, Naturopathic Medicine.
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Written By: Dr. Adam McLeod, ND

A patient waits in the doctor’s office. When he enters the doctor asks, “What brings you in here today?” The patient replies, “I have no health concerns at all. I am actually very healthy. I just want to learn how to stay healthy.” This scenario may sound bizarre to some people. Why would someone book an appointment with their doctor if they are perfectly healthy? These types of appointments need to become more common in our health care system!

In our culture there are many in the mainstream medical community that regularly speak about the importance of preventative medicine. There is no doubt that preventative medicine is effective and it ultimately saves our health care system billions of dollars in the long-term. Preventative medicine is more effective when the patient is treated before they are sick. By definition preventative medicine is the art of medicine that prevents patients from getting ill in the first place.

Patients should be encouraged to visit their doctor even when there is no health concern. Obviously regular checkups are important to ensure that the patient is indeed in good health but there also needs to be an active effort to keep them healthy. The solution to preventative medicine is not simply taking a pill to control a marker on a blood test. The solution must include getting the patient engaged in their own health.

Patients need to be actively encouraged to participate in the healing process. We live in a culture where people tend to pass on the responsibility of their health on to their doctor. Of course the doctor has some responsibility to ensure that the patient is receiving the care that they need. But the patient must also accept responsibility for his or her own healing. Be proactive and get engaged with your own healing process!

There are so many basic changes that can be made to your lifestyle that will make a substantial difference when trying to prevent an illness. Many of these changes we are all well aware of but we could use some encouragement from our doctor to make these changes. We should all exercise regularly; eat a balanced healthy diet and practice focusing our mind. Even just a few minutes of focused intention before bed can make a substantial difference in your life. It can help to reduce stress and organize your thoughts more effectively so that you can get through the next day with ease.

It can be very difficult to get some patients to make these basic positive changes in their life. A big component of the art of medicine is learning to meet the patient where they are at. Even if they are resistant to change their doctor should make an effort to encourage these positive changes at every opportunity. Developing a healthy lifestyle is a process and it is unlikely that a patient will make all of these changes at once and stick with it. Positive changes must be added over time as the patient makes strides in the direction of health.

Naturopathic doctors are experts in preventative medicine and they are trained to assess every aspect of your health and customize a treatment plan that is right for you. They can help to improve every aspect of your lifestyle in a way that will help to prevent the development of illness. Be proactive and get involved in your own healing. Your local naturopathic doctor can help you to find the path to a healthy balanced life.

For more information about Dr. Adam McLeod‘s practice visit: http://www.yaletownnaturopathic.com

Note: Due to the high volume of calls the best way to book an appointment is send an email to appointments@yaletownnaturopathic.com and the clinic will contact you when there is an available appointment.

Bacteria help kids stay healthy! March 30, 2014

Posted by Dreamhealer in Allergies, Alternative medicine, Antibiotics, Colds, Diet, Dreamhealer, Experiments, Healing, Health, Integrative Medicine, naturopathic, Naturopathic Medicine, Naturopathy, Research, Skeptics.
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By: Drs. Kay Judge and Maxine Barish-Wreden

Breaking news: Bacteria help kids stay healthy! In a study published this month in the Journal of Pediatrics, scientist found that daily probiotics help toddlers avoid certain infections. Researchers enrolled 300 children, ages 6 months to 36 months, in day care centers in a double-blinded study. Half of the children received placebos and half received probiotics.

For the children who received probiotics, it was found that there was a reduction in frequency and duration of diarrhea episodes. And surprisingly, there was also a reduction in respiratory tract infections in the children who took probiotics.

The children in the study received the probiotic Lactobaccillus reuteri daily for three months. In addition to the already-mentioned health benefits, the study found a reduction in the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work.

Other studies on probiotics have found that probiotics may help in reducing acute diarrhea, antibiotic-associated diarrhea, atopic eczema, tooth decay, C. diff. bacteria colitis, irritable bowel syndrome and inflammatory bowel disease, including pouchitis.

So what is this miracle drug? Probiotics are live microorganisms numbering over 100 trillion, including over 500 bacterial species, which normally reside in the human intestinal tract. These microorganisms help in digestion, provide the body with nutrients, help the immune system and help keep harmful microorganisms in check.

Common probiotics are Lactobacillus bulgaris, Streptococcus thermophiles, Lactobacillus acidophilus and casei, and Bifidobacteria. One can maintain a healthy balance of these “good bacteria” in the body by taking products which contain live and active cultures of these bacteria. These can include the pill and liquid probiotic supplements, as well as foods such as yogurt, and fermented foods such as brewer’s yeast, miso, sauerkraut or micro algae.

If you need additional nondairy yogurt options, yogurts made from rice, soy and coconut milk are available on the market. Some of these can contain added probiotics that provide the same benefits as regular yogurt. To ensure that you are getting the benefit of the probiotics in the foods that you are eating, pick those that state “live and active cultures” on the label. Also look for supplements that are not close to their expiration date, as the live bacteria dwindle over time.

Retrieved from: http://www.ledger-enquirer.com/2014/03/28/3027893/integrative-medicine-probiotics.html

For more information about alternative medicine check out http://www.dreamhealer.com

Grandma’s Experiences Leave a Mark on Your Genes March 2, 2014

Posted by Dreamhealer in Dreamhealer, Experiments, Genetics, Healing, Naturopathic Medicine, Research, Workshops.
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By: Dan Hurley

Your ancestors’ lousy childhoods or excellent adventures might change your personality, bequeathing anxiety or resilience by altering the epigenetic expressions of genes in the brain.

Darwin and Freud walk into a bar. Two alcoholic mice — a mother and her son — sit on two bar stools, lapping gin from two thimbles.

The mother mouse looks up and says, “Hey, geniuses, tell me how my son got into this sorry state.”

“Bad inheritance,” says Darwin.

“Bad mothering,” says Freud.

For over a hundred years, those two views — nature or nurture, biology or psychology — offered opposing explanations for how behaviors develop and persist, not only within a single individual but across generations.

And then, in 1992, two young scientists following in Freud’s and Darwin’s footsteps actually did walk into a bar. And by the time they walked out, a few beers later, they had begun to forge a revolutionary new synthesis of how life experiences could directly affect your genes — and not only your own life experiences, but those of your mother’s, grandmother’s and beyond.

The bar was in Madrid, where the Cajal Institute, Spain’s oldest academic center for the study of neurobiology, was holding an international meeting. Moshe Szyf, a molecular biologist and geneticist at McGill University in Montreal, had never studied psychology or neurology, but he had been talked into attending by a colleague who thought his work might have some application. Likewise, Michael Meaney, a McGill neurobiologist, had been talked into attending by the same colleague, who thought Meaney’s research into animal models of maternal neglect might benefit from Szyf’s perspective.

“I can still visualize the place — it was a corner bar that specialized in pizza,” Meaney says. “Moshe, being kosher, was interested in kosher calories. Beer is kosher. Moshe can drink beer anywhere. And I’m Irish. So it was perfect.”

The two engaged in animated conversation about a hot new line of research in genetics. Since the 1970s, researchers had known that the tightly wound spools of DNA inside each cell’s nucleus require something extra to tell them exactly which genes to transcribe, whether for a heart cell, a liver cell or a brain cell.

One such extra element is the methyl group, a common structural component of organic molecules. The methyl group works like a placeholder in a cookbook, attaching to the DNA within each cell to select only those recipes — er, genes — necessary for that particular cell’s proteins. Because methyl groups are attached to the genes, residing beside but separate from the double-helix DNA code, the field was dubbed epigenetics, from the prefix epi (Greek for over, outer, above).

Originally these epigenetic changes were believed to occur only during fetal development. But pioneering studies showed that molecular bric-a-brac could be added to DNA in adulthood, setting off a cascade of cellular changes resulting in cancer. Sometimes methyl groups attached to DNA thanks to changes in diet; other times, exposure to certain chemicals appeared to be the cause. Szyf showed that correcting epigenetic changes with drugs could cure certain cancers in animals.

Geneticists were especially surprised to find that epigenetic change could be passed down from parent to child, one generation after the next. A study from Randy Jirtle of Duke University showed that when female mice are fed a diet rich in methyl groups, the fur pigment of subsequent offspring is permanently altered. Without any change to DNA at all, methyl groups could be added or subtracted, and the changes were inherited much like a mutation in a gene.

Now, at the bar in Madrid, Szyf and Meaney considered a hypothesis as improbable as it was profound: If diet and chemicals can cause epigenetic changes, could certain experiences — child neglect, drug abuse or other severe stresses — also set off epigenetic changes to the DNA inside the neurons of a person’s brain? That question turned out to be the basis of a new field, behavioral epigenetics, now so vibrant it has spawned dozens of studies and suggested profound new treatments to heal the brain.

According to the new insights of behavioral epigenetics, traumatic experiences in our past, or in our recent ancestors’ past, leave molecular scars adhering to our DNA. Jews whose great-grandparents were chased from their Russian shtetls; Chinese whose grandparents lived through the ravages of the Cultural Revolution; young immigrants from Africa whose parents survived massacres; adults of every ethnicity who grew up with alcoholic or abusive parents — all carry with them more than just memories.

Like silt deposited on the cogs of a finely tuned machine after the seawater of a tsunami recedes, our experiences, and those of our forebears, are never gone, even if they have been forgotten. They become a part of us, a molecular residue holding fast to our genetic scaffolding. The DNA remains the same, but psychological and behavioral tendencies are inherited. You might have inherited not just your grandmother’s knobby knees, but also her predisposition toward depression caused by the neglect she suffered as a newborn.

Or not. If your grandmother was adopted by nurturing parents, you might be enjoying the boost she received thanks to their love and support. The mechanisms of behavioral epigenetics underlie not only deficits and weaknesses but strengths and resiliencies, too. And for those unlucky enough to descend from miserable or withholding grandparents, emerging drug treatments could reset not just mood, but the epigenetic changes themselves. Like grandmother’s vintage dress, you could wear it or have it altered. The genome has long been known as the blueprint of life, but the epigenome is life’s Etch A Sketch: Shake it hard enough, and you can wipe clean the family curse.

Voodoo Genetics 

Twenty years after helping to set off a revolution, Meaney sits behind a wide walnut table that serves as his desk. A January storm has deposited half a foot of snow outside the picture windows lining his fourth-floor corner office at the Douglas Institute, a mental health affiliate of McGill. He has the rugged good looks and tousled salt-and-pepper hair of someone found on a ski slope — precisely where he plans to go this weekend. On the floor lays an arrangement of helium balloons in various stages of deflation. “Happy 60th!” one announces.

“I’ve always been interested in what makes people different from each other,” he says. “The way we act, the way we behave — some people are optimistic, some are pessimistic. What produces that variation? Evolution selects the variance that is most successful, but what produces the grist for the mill?”

Meaney pursued the question of individual differences by studying how the rearing habits of mother rats caused lifelong changes in their offspring. Research dating back to the 1950s had shown that rats handled by humans for as little as five to 15 minutes per day during their first three weeks of life grew up to be calmer and less reactive to stressful environments compared with their non-handled littermates. Seeking to tease out the mechanism behind such an enduring effect, Meaney and others established that the benefit was not actually conveyed by the human handling. Rather, the handling simply provoked the rats’ mothers to lick and groom their pups more, and to engage more often in a behavior called arched-back nursing, in which the mother gives the pups extra room to suckle against her underside.

“It’s all about the tactile stimulation,” Meaney says.

In a landmark 1997 paper in Science, he showed that natural variations in the amount of licking and grooming received during infancy had a direct effect on how stress hormones, including corticosterone, were expressed in adulthood. The more licking as babies, the lower the stress hormones as grown-ups. It was almost as if the mother rats were licking away at a genetic dimmer switch. What the paper didn’t explain was how such a thing could be possible.

“What we had done up to that point in time was to identify maternal care and its influence on specific genes,” Meaney says. “But epigenetics wasn’t a topic I knew very much about.”

And then he met Szyf.

Postnatal Inheritance 

“I was going to be a dentist,” Szyf says with a laugh. Slight, pale and balding, he sits in a small office at the back of his bustling laboratory — a room so Spartan, it contains just a single picture, a photograph of two embryos in a womb.

Needing to write a thesis in the late 1970s for his doctorate in dentistry at Hebrew University of Jerusalem, Szyf approached a young biochemistry professor named Aharon Razin, who had recently made a splash by publishing his first few studies in some of the world’s top scientific journals. The studies were the first to show that the action of genes could be modulated by structures called methyl groups, a subject about which Szyf knew precisely nothing. But he needed a thesis adviser, and Razin was there. Szyf found himself swept up to the forefront of the hot new field of epigenetics and never looked back.

Until researchers like Razin came along, the basic story line on how genes get transcribed in a cell was neat and simple. DNA is the master code, residing inside the nucleus of every cell; RNA transcribes the code to build whatever proteins the cell needs. Then some of Razin’s colleagues showed that methyl groups could attach to cytosine, one of the chemical bases in DNA and RNA.

It was Razin, working with fellow biochemist Howard Cedar, who showed these attachments weren’t just brief, meaningless affairs. The methyl groups could become married permanently to the DNA, getting replicated right along with it through a hundred generations. As in any good marriage, moreover, the attachment of the methyl groups significantly altered the behavior of whichever gene they wed, inhibiting its transcription, much like a jealous spouse. It did so, Razin and Cedar showed, by tightening the thread of DNA as it wrapped around a molecular spool, called a histone, inside the nucleus. The tighter it is wrapped, the harder to produce proteins from the gene.

Consider what that means: Without a mutation to the DNA code itself, the attached methyl groups cause long-term, heritable change in gene function. Other molecules, called acetyl groups, were found to play the opposite role, unwinding DNA around the histone spool, and so making it easier for RNA to transcribe a given gene.

By the time Szyf arrived at McGill in the late 1980s, he had become an expert in the mechanics of epigenetic change. But until meeting Meaney, he had never heard anyone suggest that such changes could occur in the brain, simply due to maternal care.

“It sounded like voodoo at first,” Szyf admits. “For a molecular biologist, anything that didn’t have a clear molecular pathway was not serious science. But the longer we talked, the more I realized that maternal care just might be capable of causing changes in DNA methylation, as crazy as that sounded. So Michael and I decided we’d have to do the experiment to find out.”

Actually, they ended up doing a series of elaborate experiments. With the assistance of postdoctoral researchers, they began by selecting mother rats who were either highly attentive or highly inattentive. Once a pup had grown up into adulthood, the team examined its hippocampus, a brain region essential for regulating the stress response. In the pups of inattentive mothers, they found that genes regulating the production of glucocorticoid receptors, which regulate sensitivity to stress hormones, were highly methylated; in the pups of conscientious moms, the genes for the glucocorticoid receptors were rarely methylated.

Methylation just gums up the works. So the less the better when it comes to transcribing the affected gene. In this case, methylation associated with miserable mothering prevented the normal number of glucocorticoid receptors from being transcribed in the baby’s hippocampus. And so for want of sufficient glucocorticoid receptors, the rats grew up to be nervous wrecks.

To demonstrate that the effects were purely due to the mother’s behavior and not her genes, Meaney and colleagues performed a second experiment. They took rat pups born to inattentive mothers and gave them to attentive ones, and vice versa. As they predicted, the rats born to attentive mothers but raised by inattentive ones grew up to have low levels of glucocorticoid receptors in their hippocampus and behaved skittishly. Likewise, those born to bad mothers but raised by good ones grew up to be calm and brave and had high levels of glucocorticoid receptors.

Before publishing their findings, Meaney and Szyf conducted a third crucial experiment, hoping to overwhelm the inevitable skeptics who would rise up to question their results. After all, it could be argued, what if the epigenetic changes observed in the rats’ brains were not directly causing the behavioral changes in the adults, but were merely co-occurring? Freud certainly knew the enduring power of bad mothers to screw up people’s lives. Maybe the emotional effects were unrelated to the epigenetic change.

To test that possibility, Meaney and Szyf took yet another litter of rats raised by rotten mothers. This time, after the usual damage had been done, they infused their brains with trichostatin A, a drug that can remove methyl groups. These animals showed none of the behavioral deficits usually seen in such offspring, and their brains showed none of the epigenetic changes.

“It was crazy to think that injecting it straight into the brain would work,” says Szyf. “But it did. It was like rebooting a computer.”

Despite such seemingly overwhelming evidence, when the pair wrote it all up in a paper, one of the reviewers at a top science journal refused to believe it, stating he had never before seen evidence that a mother’s behavior could cause epigenetic change.

“Of course he hadn’t,” Szyf says. “We wouldn’t have bothered to report the study if it had already been proved.”

In the end, their landmark paper, “Epigenetic programming by maternal behavior,” was published in June 2004 in the journal Nature Neuroscience.

Meaney and Szyf had proved something incredible. Call it postnatal inheritance: With no changes to their genetic code, the baby rats nonetheless gained genetic attachments due solely to their upbringing — epigenetic additions of methyl groups sticking like umbrellas out the elevator doors of their histones, gumming up the works and altering the function of the brain.

The Beat Goes On

Together, Meaney and Szyf have gone on to publish some two-dozen papers, finding evidence along the way of epigenetic changes to many other genes active in the brain. Perhaps most significantly, in a study led by Frances Champagne — then a graduate student in Meaney’s lab, now an associate professor with her own lab at Columbia University in New York — they found that inattentive mothering in rodents causes methylation of the genes for estrogen receptors in the brain. When those babies grow up, the resulting decrease of estrogen receptors makes them less attentive to their babies. And so the beat goes on.

As animal experiments continue apace, Szyf and Meaney have entered into the next great step in the study of behavioral epigenetics: human studies. In a 2008 paper, they compared the brains of people who had committed suicide with the brains of people who had died suddenly of factors other than suicide. They found excess methylation of genes in the suicide brains’ hippocampus, a region critical to memory acquisition and stress response. If the suicide victims had been abused as children, they found, their brains were more methylated.

Why can’t your friend “just get over” her upbringing by an angry, distant mother? Why can’t she “just snap out of it”? The reason may well be due to methyl groups that were added in childhood to genes in her brain, thereby handcuffing her mood to feelings of fear and despair.

Of course, it is generally not possible to sample the brains of living people. But examining blood samples in humans is routine, and Szyf has gone searching there for markers of epigenetic methylation. Sure enough, in 2011 he reported on a genome-wide analysis of blood samples taken from 40 men who participated in a British study of people born in England in 1958.

All the men had been at a socioeconomic extreme, either very rich or very poor, at some point in their lives ranging from early childhood to mid-adulthood. In all, Szyf analyzed the methylation state of about 20,000 genes. Of these, 6,176 genes varied significantly based on poverty or wealth. Most striking, however, was the finding that genes were more than twice as likely to show methylation changes based on family income during early childhood versus economic status as adults.

Timing, in other words, matters. Your parents winning the lottery or going bankrupt when you’re 2 years old will likely affect the epigenome of your brain, and your resulting emotional tendencies, far more strongly than whatever fortune finds you in middle age.

Last year, Szyf and researchers from Yale University published another study of human blood samples, comparing 14 children raised in Russian orphanages with 14 other Russian children raised by their biological parents. They found far more methylation in the orphans’ genes, including many that play an important role in neural communication and brain development and function.

“Our study shows that the early stress of separation from a biological parent impacts long-term programming of genome function; this might explain why adopted children may be particularly vulnerable to harsh parenting in terms of their physical and mental health,” said Szyf’s co-author, psychologist Elena Grigorenko of the Child Study Center at Yale. “Parenting adopted children might require much more nurturing care to reverse these changes in genome regulation.”

A case study in the epigenetic effects of upbringing in humans can be seen in the life of Szyf’s and Meaney’s onetime collaborator, Frances Champagne. “My mom studied prolactin, a hormone involved in maternal behavior. She was a driving force in encouraging me to go into science,” she recalls. Now a leading figure in the study of maternal influence, Champagne just had her first child, a daughter. And epigenetic research has taught her something not found in the What to Expect books or even her mother’s former lab.

“The thing I’ve gained from the work I do is that stress is a big suppressor of maternal behavior,” she says. “We see it in the animal studies, and it’s true in humans. So the best thing you can do is not to worry all the time about whether you’re doing the right thing. Keeping the stress level down is the most important thing. And tactile interaction — that’s certainly what the good mother rats are doing with their babies. That sensory input, the touching, is so important for the developing brain.”

The Mark Of Cain 

The message that a mother’s love can make all the difference in a child’s life is nothing new. But the ability of epigenetic change to persist across generations remains the subject of debate. Is methylation transmitted directly through the fertilized egg, or is each infant born pure, a methylated virgin, with the attachments of methyl groups slathered on solely by parents after birth?

Neuroscientist Eric Nestler of the Icahn School of Medicine at Mount Sinai in New York has been seeking an answer for years. In one study, he exposed male mice to 10 days of bullying by larger, more aggressive mice. At the end of the experiment, the bullied mice were socially withdrawn.

To test whether such effects could be transmitted to the next generation, Nestler took another group of bullied mice and bred them with females, but kept them from ever meeting their offspring.

Despite having no contact with their depressed fathers, the offspring grew up to be hypersensitive to stress. “It was not a subtle effect; the offspring were dramatically more susceptible to developing signs of depression,” he says.

In further testing, Nestler took sperm from defeated males and impregnated females through in vitro fertilization. The offspring did not show most of the behavioral abnormalities, suggesting that epigenetic transmission may not be at the root. Instead, Nestler proposes, “the female might know she had sex with a loser. She knows it’s a tainted male she had sex with, so she cares for her pups differently,” accounting for the results.

Despite his findings, no consensus has yet emerged. The latest evidence, published in the Jan. 25 issue of the journal Science, suggests that epigenetic changes in mice are usually erased, but not always. The erasure is imperfect, and sometimes the affected genes may make it through to the next generation, setting the stage for transmission of the altered traits in descendants as well.

What’s Next?

The studies keep piling on. One line of research traces memory loss in old age to epigenetic alterations in brain neurons. Another connects post-traumatic stress disorder to methylation of the gene coding for neurotrophic factor, a protein that regulates the growth of neurons in the brain.

If it is true that epigenetic changes to genes active in certain regions of the brain underlie our emotional and intellectual intelligence — our tendency to be calm or fearful, our ability to learn or to forget — then the question arises: Why can’t we just take a drug to rinse away the unwanted methyl groups like a bar of epigenetic Irish Spring?

The hunt is on. Giant pharmaceutical and smaller biotech firms are searching for epigenetic compounds to boost learning and memory. It has been lost on no one that epigenetic medications might succeed in treating depression, anxiety and post-traumatic stress disorder where today’s psychiatric drugs have failed.

But it is going to be a leap. How could we be sure that epigenetic drugs would scrub clean only the dangerous marks, leaving beneficial — perhaps essential — methyl groups intact? And what if we could create a pill potent enough to wipe clean the epigenetic slate of all that history wrote? If such a pill could free the genes within your brain of the epigenetic detritus left by all the wars, the rapes, the abandonments and cheated childhoods of your ancestors, would you take it?

Retrieved from: http://discovermagazine.com/2013/may/13-grandmas-experiences-leave-epigenetic-mark-on-your-genes#.UxPna_RdXWo

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